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Table 2 Genotype and allele distributions of SMAD3 rs12901499 polymorphism in the included studies

From: Association between SMAD3 gene polymorphisms and osteoarthritis risk: a systematic review and meta-analysis

Study

Genotype distribution

Allele distribution

Association findings

OA

Control

OA

Control

AA

AG

GG

AA

AG

GG

A

G

A

G

Valdes-Discovery set

NA

NA

NA

NA

NA

NA

419

635

489

551

G allele↑

Valdes-Nottingham

NA

NA

NA

NA

NA

NA

1788

2336

698

768

G allele↑

Valdes-Chingford

NA

NA

NA

NA

NA

NA

316

388

477

499

NS

Valdes-Hertfordshire

NA

NA

NA

NA

NA

NA

134

200

779

955

NS

Valdes-Estonia

NA

NA

NA

NA

NA

NA

67

79

481

417

NS

Jiang

47

141

25

114

83

23

235

191

311

129

G allele↑, GG genotype↑

Su

142

247

129

116

228

124

531

505

460

476

NS

Sharma

85

70

75

90

92

52

240

220

272

196

G allele↑, GG genotype↑

Zhang

82

173

91

81

202

111

337

355

364

424

GG genotype↓

Zhong

10

200

290

20

610

450

220

780

650

1510

G allele↑, GG genotype↑

  1. NA data not available, ↑/↓ increase/decrease the risk of OA, NS not significant