Table 1 Characteristics of included studies
Study | Year | Country | Ethnicity | Design | OA site | Genotyping method | Sample size (F/M) | HWE | NOS | |
|---|---|---|---|---|---|---|---|---|---|---|
OA | Control | |||||||||
Valdes-Discovery set | 2010 | UK | Caucasian | CC | Knee, hip | Allele-specific PCR | 477 (NA) | 520 (NA) | Y | 7 |
Valdes-Nottingham | 2010 | UK | Caucasian | CC | Knee, hip | Allele-specific PCR | 2014 (NA) | 733 (NA) | Y | 7 |
Valdes-Chingford | 2010 | UK | Caucasian | Cohort | Knee, hip | Allele-specific PCR | 317 (317/0) | 488 (488/0) | Y | 9 |
Valdes-Hertfordshire | 2010 | UK | Caucasian | Cohort | Knee | Allele-specific PCR | 167 (NA) | 867 (NA) | Y | 8 |
Valdes-Estonia | 2010 | Estonia | Caucasian | Cohort | Knee | Allele-specific PCR | 68 (NA) | 449 (NA) | Y | 8 |
Jiang | 2013 | China | Asian | CC | Knee | PCR-RFLP | 232 (159/73) | 236 (91/145) | Y | 7 |
Su | 2015 | China | Asian | CC | Knee | PCR-RFLP | 518 (328/190) | 468 (261/207) | Y | 7 |
Sharma | 2017 | India | Asian | CC | Knee | Allele-specific PCR | 450 (230/220) | 458 (234/224) | Y | 8 |
Zhang | 2018 | China | Asian | CC | Knee | Allele-specific PCR | 350 (99/251) | 400 (110/210) | Y | 8 |
Zhong | 2018 | China | Asian | CC | Hip | Allele-specific PCR | 500 (260/240) | 1080 (580/500) | Y | 8 |