Fig. 1From: Combined detection of COMP and CS846 biomarkers in experimental rat osteoarthritis: a potential approach for assessment and diagnosis of osteoarthritisMacroscopic observation of tibial plateau. a Tibial plateau of rats in the control group showed a smooth cartilage surface, and no cartilage defects or osteophytes. b After 2Â weeks of surgery, the joint surface was slightly rough (arrow). c The joint surface was partially recessed at 4Â weeks of after surgery (arrow). d The joint surface was rough and matte at 6Â weeks of after surgery (rectangle frame). e The articular cartilage was severely damaged at 8Â weeks after surgery (rectangle frame). f The joint surface showed a large area of ulcers, and subchondral bone was exposed at 10Â weeks after surgery (arrow)Back to article page