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Fig. 3 | Journal of Orthopaedic Surgery and Research

Fig. 3

From: Combination therapy with low-dose teriparatide and zoledronate contributes to fracture healing on rat femoral fracture model

Fig. 3

Bone histological imaging (demineralized specimens: HE staining) (× 1) (× 40). In the C (a) and T(1)+ZA groups (b), verifying the fracture site by HE staining identified the fracture and confirmed extensive chondrogenesis. Furthermore, while several specimens demonstrated thin immature callus formation, callus continuity could not be confirmed in many specimens. And cartilaginous bone metaplasia was not observed. Although a few chondrocytes, suggesting bone metaplasia, were identified in the T(1)+ZA group (b), they were enlarged. Compared to the C group, the fracture line was unclear. Furthermore, in the T(10) + ZA group (c), chondrocytes could not be identified, but mature callus and advanced bone union were confirmed (c).

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