Table 2 Core pathways and their associated genes found
GOID | GOTerm | Term P value | % associated genes | Associated genes found |
|---|---|---|---|---|
GO:0004915 | Estrogen signaling pathway | 130.0E−3 | 6.12 | [CALM3, CALML4, HSPA1L, HSPA8, ITPR3, MAPK3] |
GO:0004390 | Hippo signaling pathway | 62.0E−3 | 5.84 | [ACTG1, APC2, BIRC2, BMP2, FRMD6, LLGL2, RASSF6, SOX2, WNT8A] |
GO:0004520 | Adherens junction | 290.0E−3 | 5.56 | [ACTG1, MAPK3, PTPRM, WAS] |
GO:0004657 | IL-17 signaling pathway | 220.0E−3 | 5.38 | [IL6, MAPK15, MAPK3, S100A8, S100A9] |
GO:0004621 | NOD-like receptor signaling pathway | 110.0E−3 | 5.29 | [BIRC2, ERBIN, IFNA1, IFNAR2, IL6, ITPR3, MAPK3, RNASEL, TP53BP1] |
GO:0004210 | Apoptosis | 210.0E−3 | 5.07 | [ACTG1, BIRC2, ITPR3, LMNA, MAPK3, PDPK1, TUBA3D] |
GO:0004371 | Apelin signaling pathway | 210.0E−3 | 5.07 | [CALM3, CALML4, GNG11, ITPR3, MAPK3, PRKAG2, RYR2] |
GO:0004722 | Neurotrophin signaling pathway | 270.0E−3 | 5.04 | [CALM3, CALML4, IRAK2, MAGED1, MAPK3, PDPK1] |
GO:0004020 | Calcium signaling pathway | 190.0E−3 | 4.95 | [CALM3, CALML4, CHRM3, ITPR3, P2RX2, PTGER3, RYR2, SLC25A4, STIM2] |
GO:0004512 | ECM–receptor interaction | 330.0E−3 | 4.88 | [COL1A2, COL2A1, COL6A1, HSPG2] |
GO:0004620 | Toll-like receptor signaling pathway | 380.0E−3 | 4.81 | [IFNA1, IFNAR2, IL6, MAP2K3, MAPK3] |
GO:0004150 | mTOR signaling pathway | 340.0E−3 | 4.61 | [ATP6V1B2, DEPDC5, EIF4E, MAPK3, PDPK1, PRR5, WNT8A] |
GO:0004068 | FoxO signaling pathway | 310.0E−3 | 4.55 | [BCL6, CCNG2, IL6, MAPK3, PDPK1, PRKAG2] |
GO:0004510 | Focal adhesion | 290.0E−3 | 4.52 | [ACTG1, BCAR1, BIRC2, COL1A2, COL2A1, COL6A1, MAPK3, PARVB, PDPK1] |
GO:0004514 | Cell adhesion molecules (CAMs) | 460.0E−3 | 4.14 | [CADM1, CLDN5, NCAM2, PTPRC, PTPRM, SELP] |