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Table 3 Clot kinetics and lysis parameters for TXA and non-TXA patients at baseline, after bone cut, and end of surgery as measured on EXTEM, FIBTEM and INTEM tests

From: Tranexamic acid is associated with selective increase in inflammatory markers following total knee arthroplasty (TKA): a pilot study

Test

Group

Time

CT (s)

CFT (s)

Alpha Angle (°)

LI30 (%)

LI45 (%)

ML (%)

EXTEM

Non-TXA

Baseline

59 ± 3

96 ± 2

72 ± 3

100 ± 0

98.1 ± 0.4

3.1 ± 1.0

Bone Cut

53 ± 1

76 ± 7

76 ± 2*

100 ± 0

97.4 ± 0.5

6.3 ± 0.8*

Surgery End

51 ± 3

75 ± 7

73 ± 3

100 ± 0

98.7 ± 0.3¥

3.9 ± 0.6¥

TXA

Baseline

64 ± 4

70 ± 7

76 ± 1

98.8 ± 1.2

95.6 ± 1.9

7.9 ± 1.9

Bone Cut

59 ± 5

67 ± 6

78 ± 1

99.8 ± 0.3

97.3 ± 0.6

6.5 ± 1.0

Surgery End

65 ± 3¶

89 ± 14

73 ± 2

100 ± 0

98.3 ± .4

4.4 ± 0.8

FIBTEM

Non-TXA

Baseline

59 ± 6

884 ± 476

76 ± 1

99.1 ± 0.9

99.3 ± 0.7

1.4 ± 1.3

Bone Cut

53 ± 3

797 ± 604

73 ± 2

100 ± 0

99.9 ± .10

0.5 ± 0.3

Surgery End

49 ± 2

1483 ± 576

67 ± 7

99.9 ± 0.1

100 ± 0

0.4 ± 0.2

TXA

Baseline

66 ± 5

1020 ± 480

74 ± 2

100 ± 0

99.5 ± 0.23

1.1 ± 0.4

Bone Cut

54 ± 4*

403 ± 300

76 ± 1*

98.8 ± 0.7

98.3 ± 1.1

2.8 ± 1.3

Surgery End

68 ± 5¶

480 ± 301

70 ± 2

99.9 ± 0.1

99.8 ± 0.2

1.1 ± 0.4

INTEM

Non-TXA

Baseline

204 ± 15

104 ± 16

71 ± 2

99.7 ± 0.3

97.7 ± 0.7

4.6 ± 1.0

Bone Cut

164 ± 10*

71 ± 8*

76 ± 2*

99.7 ± 0.2

96.6 ± 0.5

6.3 ± 0.6

Surgery End

162 ± 13*

69 ± 10*

73 ± 2

100 ± 0

98.3 ± 0.4

4.1 ± 0.8

TXA

Baseline

170 ± 11

69 ± 8¶

76 ± 2¶

99.7 ± 0.1

95.9 ± 0.5

6.8 ± 0.8

Bone Cut

149 ± 8*

65 ± 4

77 ± 1

99.8 ± 0.1

97 ± 0.6*

5.8 ± 0.7

Surgery End

154 ± 12

101 ± 31

73 ± 4

100 ± 0*

97.9 ± 0.4§

4.8 ± 0.7§

  1. Data represent mean ± SEM. CT clot time, CFT clot formation time, LI lysis index, ML maximum lysis. n = 12 for TXA group; n = 11 for non-TXA group. *p < 0.05 compared with baseline; ¥p < 0.05 compared with Bone Cut; §p < 0.05 compared with baseline and bone cut; ¶p < 0.05 compared non-TXA group