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Table 2 The GRADE evidence quality

From: Comparison of suprapatellar and infrapatellar intramedullary nailing for tibial shaft fractures: a systematic review and meta-analysis

Quality assessment No. of patients Effect Quality Importance
No. of studies Design Limitations Inconsistency Indirectness Imprecision IP groups SP groups
Total blood loss
 4 RCT Serious limitations No serious inconsistency No serious indirectness No serious imprecision 142 151 WMD = 7.92, 95% CI 1.15 to 14.68 High Critical
VAS scores
 4 RCT Serious limitations No serious inconsistency No serious indirectness No serious imprecision 142 151 WMD = 0.70, 95% CI 0.570 to 0.83 High Critical
Range of motion
 3 RCT Serious limitations No serious inconsistency No serious indirectness No serious imprecision 112 113 WMD = − 1.28, 95% CI − 3.16 to 0.59 High Critical
Lysholm knee scores
 3 RCT Serious limitations No serious inconsistency No serious indirectness No serious imprecision 112 113 WMD = − 5.58, 95% CI − 7.33 to − 3.83 High Critical
Fluoroscopy times
 2 RCT Serious limitations Serious inconsistency No serious indirectness No serious imprecision 111 119 WMD = 26.70, 95% CI 3.15 to 50.25 Moderate Critical
Length of hospital stay
 3 RCT Serious limitations No serious inconsistency No serious indirectness No serious imprecision 125 130 WMD = − 0.05, 95% CI − 0.33 to 0.23 High Critical
Postoperative complications
 3 RCT Serious limitations No serious inconsistency No serious indirectness No serious imprecision 125 130 RD = 0.01, 95% CI − 0.03 to 0.04 High Critical