FTO variant is not associated with osteoarthritis in the Chinese Han population: replication study for a genome-wide association study identified risk loci

Table 4 Associations between FTO polymorphism and BMI when stratified by gender and OA status

Groups compared	CC vs. other combined			TT vs. other combined			C allele vs. T allele			All genotype
Groups compared	P value	OR	95% CI	P value	OR	95% CI	P value	OR	95% CI	P value
Total overweight and obese cases (n = 892) vs. controls (n = 842)	0.867	0.984	0.811–1.19	0.901	1.012	0.778–1.33	0.856	0.987	0.861–1.13	0.983
Overweight and obese cases (n = 423) vs. controls (n = 405) in females	0.835	0.971	0.734–1.28	0.738	1.07	0.725–1.57	0.750	0.968	0.794–1.18	0.940
Overweight and obese cases (n = 469) vs. controls (n = 437) in males	0.973	0.995	0.762–1.30	0.882	0.972	0.670–1.41	0.959	1.00	0.831–1.22	0.985
Overweight and obese cases (n = 482) vs. controls (n = 408) in OA cases	0.818	1.03	0.786–1.36	0.966	1.01	0.692–1.47	0.888	1.01	0.837–1.23	0.967
Overweight and obese cases (n = 410) vs. controls (n = 434) in OA controls	0.707	0.948	0.720–1.25	0.886	1.03	0.701–1.51	0.731	0.966	0.793–1.18	0.931

ISSN: 1749-799X