FTO variant is not associated with osteoarthritis in the Chinese Han population: replication study for a genome-wide association study identified risk loci

Table 3 Association of FTO polymorphism (rs8044769) with osteoarthritis when stratified by gender and BMI

Groups compared	CC vs. other combined			TT vs. other combined			C allele vs. T allele			All genotype
Groups compared	P value	OR	95% CI	P value	OR	95% CI	P value	OR	95% CI	P value
Female cases (n = 665) vs. controls (n = 163)	0.802	0.956	0.673–1.36	0.402	0.819	0.513–1.31	0.801	1.03	0.805–1.32	0.604
Male cases (n = 225) vs. controls (n = 681)	0.160	0.799	0.584–1.09	0.666	1.098	0.718–1.68	0.222	0.878	0.702–1.09	0.373
Normal weight cases (n = 400) vs. controls (n = 422)	0.241	0.845	0.639–1.12	0.831	1.04	0.706–1.54	0.345	0.908	0.744–1.11	0.494
Overweight cases (n = 376) vs. controls (n = 368)	0.448	0.892	0.663–1.20	0.742	0.934	0.621–1.40	0.712	0.961	0.780–1.19	0.623
Obese cases (n = 106) vs. controls (n = 42)	0.782	1.11	0.532–2.31	0.616	1.32	0.450–3.85	0.954	0.985	0.583–1.66	0.790

ISSN: 1749-799X