Collagen IX gene polymorphisms and lumbar disc degeneration: a systematic review and meta-analysis

Table 2 Genotype and allele frequency of COL9A2 and COL9A3 gene polymorphisms in LDD patients and controls

Study			Case group					Control group					HWE for control
Author	Year	Ethnicity	11	12	22	1	2	11	12	22	1	2	HWE for control
rs12077871 (C vs. T)
Annunen et al. [4]	1999	Caucasian	NM	NM	NM	308	6	NM	NM	NM	348	0
Noponen-Hietala et al. [15]	2003	Caucasian	28	1	0	57	1	56	0	0	112	0	1.000000
Seki et al. [17]	2006	Asian	370	91	9	831	109	504	136	14	1144	164	0.184822
Song et al. [18]	2010	Asian	95	30	0	220	30	100	24	1	224	26	0.735473
Hyun et al. [14]	2011	Asian	155	46	4	356	54	76	22	3	174	28	0.377303
Rathod et al. [16]	2012	Asian	43	43	15	128	72	83	17	0	183	17	0.352901
rs12722877 (C vs. G)
Paassilta et al. [12]	2001	Caucasian	NM	NM	NM	290	22	NM	NM	NM	312	22
Seki et al. [17]	2006	Asian	414	54	1	882	56	576	76	2	1228	80	0.761095
Song et al. [18]	2010	Asian	103	22	0	228	22	109	17	0	235	17	0.416784
Chen et al. [19]	2013	Asian	158	98	24	414	146	120	113	35	353	183	0.306985
rs7533552 (C vs. G)
Annunen et al. [4]	1999	Caucasian	NM	NM	NM	228	86	NM	NM	NM	258	90
Seki et al. [17]	2006	Asian	217	221	32	655	285	327	277	50	931	377	0.40912
Song et al. [18]	2010	Asian	21	63	41	105	145	25	67	33	117	133	0.39295
Hyun et al. [14]	2011	Asian	86	97	22	269	141	41	47	13	129	73	0.934487
Meng et al. [20]	2016	Asian	68	113	34	249	181	81	131	18	293	167	0.000449
rs61734651 (C vs. T)
Paassilta et al. [12]	2001	Caucasian	131	38	2	300	42	291	30	0	612	30	0.3798
Noponen-Hietala et al. [15]	2003	Caucasian	25	3	1	53	5	56	0	0	112	0	1.000000
Eskola et al. [21]	2010	Caucasian	57	9	0	123	9	123	30	1	276	32	0.566482
Rathod et al. [16]	2012	Asian	95	5	0	195	5	93	7	0	193	7	0.716846

11, 12, and 22 indicate CC, TC, and TT for rs12077871; CC, CG, and GG for rs12722877; AA, GA, and GG for rs7533552; CC, TC, and TT for rs61734651, respectively
NM not mentioned

ISSN: 1749-799X