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Table 1 Characteristics of the case-control studies included in systematic review

From: Collagen IX gene polymorphisms and lumbar disc degeneration: a systematic review and meta-analysis

First author

Year

Population

Ethnicity

Number of cases/controls

Disease

Diagnostic criteria

Control group

Genotyping determination

CASP

rs12077871

 

 Annunen et al. [4]

1999

Finland

Caucasian

157/174

LDD

MRI, CT

Healthy normal without spine-related problems

PCR-seq

18

 Noponen-Hietala et al. [15]

2003

Finland

Caucasian

29/56

LDD

MRI, CT

Patients without spine-related problems

PCR-seq CSGE

20

 Seki et al. [17]

2006

Japan

Asian

470/654

LDD

MRI, PR

NM

PCR-seq

19

 Song et al. [18]

2010

China

Asian

125/125

LDD

MRI, PR

Patients without LDD

TaqMan assay

18

 Hyun et al. [14]

2011

Korean

Asian

205/101

LDD

MRI

Patients without spine-related problems

PCR-seq

20

 Rathod et al. [16]

2012

India

Asian

100/100

LDD

MRI

Patients without spine-related problems

TaqMan assay

19

rs12722877

 

 Paassilta et al. [12]

2001

Finland

Caucasian

156/167

LDD

MRI, CT

Healthy normal, patients with osteoarthritis

PCR-seq CSGE

20

 Seki et al. [17]

2006

Japan

Asian

469/654

LDD

MRI, PR

NM

PCR-seq

19

 Song et al. [18]

2010

China

Asian

125/126

LDD

MRI, PR

Patients without LDD

TaqMan assay

18

 Chen et al. [19]

2013

China

Asian

280/268

LDD

MRI, CT, PR

Patients without LDD

TaqMan assay

18

rs7533552

 

 Annunen et al. [4]

1999

Finland

Caucasian

157/174

LDD

MRI, CT

Healthy normal, patients with osteoarthritis

PCR-seq

18

 Seki et al. [17]

2006

Japan

Asian

470/654

LDD

MRI, PR

NM

TaqMan assay

19

 Song et al. [18]

2010

China

Asian

125/125

LDD

MRI, PR

Patients without LDD

TaqMan assay

18

 Hyun et al. [14]

2011

Korean

Asian

205/101

LDD

MRI

Patients without spine-related and arthritic problems

PCR-seq

20

 Meng et al. [20]

2016

China

Asian

215/230

LDD

MRI, CT

Healthy

PCR-seq

19

rs61734651

 

 Paassilta et al. [12]

2001

Finland

Caucasian

156/167

LDD

MRI, CT

Healthy normal, patients with osteoarthritis

PCR-seq CSGE

20

 Noponen-Hietala et al. [15]

2003

Finland

Caucasian

29/56

LDD

MRI, CT

Patients without spine-related problems

PCR-seq CSGE

20

 Eskola et al. [21]

2010

Danish

Caucasian

154/66

LDD

MRI

Patients without spine-related problems

PCR-seq

19

 Rathod et al. [16]

2012

India

Asian

100/100

LDD

MRI

Patients without spine-related problems

TaqMan assay

19

  1. NM not mentioned, MRI magnetic resonance imaging, CT computerized tomography, PR plain radiographs, CASP Critical Appraisal Skills Programme