Specific microRNA signatures responsible for immune disturbance related to hip fracture in aged rats

Table 2 Significantly differentially expressed miRNAs in serum of hip fracture rats with immune disturbance

Types of miRNAs	Function	Fold-change	P value
rno-miR-130a-3p	Inhibited cell proliferation, invasion, and migration	− 57.43	0.0226
rno-miR-143-3p	Inhibited cell proliferation and migration/invasion	− 56.63	0.0149
rno-miR-223-3p	An oncogene or tumor suppressor gene	− 49.46	0.0249
rno-miR-7a-5p	Inhibited cell proliferation	− 37.7	0.203
rno-miR-363-3p	Inhibited cell proliferation	− 28.08	0.0828
rno-miR-451-3p	Regulated tumor cell migration and cancer progression	− 25.15	0.0723
rno-miR-138-5p	Regulated cell radiation sensitivity	− 19.85	0.0157
rno-miR-150-5p	EV release from cardiac cells	3.92	0.0184
rno-miR-125b-1-3p	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins	2.87	0.062
rno-miR-6324	Inhibited sphingomyelin metabolism	2.83	0.718
rno-miR-455-3p	Inhibited cell proliferation	2.71	0.0448
rno-miR-494-3p	Inhibited cell proliferation	2.69	0.0871
rno-miR-30a-3p	Inhibited cell autophagy, migration, and invasion	2.50	0.09

ISSN: 1749-799X