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Table 2 The significantly enriched GO and KEGG terms of the 17 DEGs

From: A time-course microarray data analysis reveals consistent dysregulated genes and upstream microRNAs in autoantibody-mediated arthritis

Term

Number

P value

Gene lists

GO term

GO_BP: immune response

11

5.86E−12

Cxcl1, Ccl2, Gp49a, Ccr2, Il1rn, Ccl9, Clec4a2, AF251705, Clec4d, Fcgr1, Ccl7

GO_BP: response to wounding

7

1.09E−06

Cxcl1, Arg1, Ccl2, Ccr2, Saa3, Fcgr1, Ccl7

GO_BP: inflammatory response

6

3.12E−06

Cxcl1, Ccl2, Ccr2, Saa3, Fcgr1, Ccl7

GO_MF: chemokine activity

4

4.66E−06

Cxcl1, Ccl2, Ccl9, Ccl7

GO_MF: chemokine receptor binding

4

5.05E−06

Cxcl1, Ccl2, Ccl9, Ccl7

GO_CC: extracellular space

7

1.65E−05

Cxcl1, Arg1, Ccl2, Il1rn, Saa3, Ccl9, Ccl7

GO_BP: defense response

6

8.70E−05

Cxcl1, Ccl2, Ccr2, Saa3, Fcgr1, Ccl7

GO_CC: extracellular region part

7

1.70E−04

Cxcl1, Arg1, Ccl2, Il1rn, Saa3, Ccl9, Ccl7

GO_MF: cytokine activity

4

4.92E−04

Cxcl1, Ccl2, Ccl9, Ccl7

GO_BP: chemotaxis

3

6.25E−03

Ccl2, Ccl9, Ccl7

GO_BP: taxis

3

6.25E−03

Ccl2, Ccl9, Ccl7

GO_CC: extracellular region

7

9.88E−03

Cxcl1, Arg1, Ccl2, Il1rn, Saa3, Ccl9, Ccl7

GO_BP: locomotory behavior

3

2.78E−02

Ccl2, Ccl9, Ccl7

GO_MF: carbohydrate binding

3

3.20E−02

Clec4a2, Clec4d, Ccl7

KEGG pathway

mmu04062:chemokine signaling pathway

5

6.21E−05

Cxcl1, Ccl2, Ccr2, Ccl9, Ccl7

mmu04060:cytokine-cytokine receptor interaction

5

1.95E−04

Cxcl1, Ccl2, Ccr2, Ccl9, Ccl7

mmu04621:NOD-like receptor signaling pathway

3

3.08E−03

Cxcl1, Ccl2, Ccl7

  1. GO Gene Ontology, KEGG Kyoto Encyclopedia of Genes and Genomes; DEGs differentially expressed genes; BP biological process; MF molecular function; CC cellular component. Gene names: AF251705 cDNA sequence AF251705; Arg1 arginase, liver; Ccl2 chemokine (C-C motif) ligand 2; Ccl7 chemokine (C-C motif) ligand 7; Ccl9 chemokine (C-C motif) ligand 9; Ccr2 chemokine (C-C motif) receptor 2; Clec4a2 C-type lectin domain family 4, member a2; Clec4d C-type lectin domain family 4, member d; Cxcl1 chemokine (C-X-C motif) ligand 1; Fcgr1 Fc receptor, IgG, high affinity; Gp49a glycoprotein 49 A; Il1rn interleukin 1 receptor antagonist; Saa3 serum amyloid A 3