Table 3 Hub genes in the protein–protein interaction network
Gene | Degree | Gene | Betweenness | Gene | Closeness |
|---|---|---|---|---|---|
Agt | 39 | Agt | 13,427.92 | Agt | 2.21E−05 |
Lpar3 | 26 | Ar | 8585.025 | Srebf1 | 2.21E−05 |
Gnai1 | 25 | Pla2g2d | 8001.098 | Ccr2 | 2.21E−05 |
Ccr5 | 24 | Srebf1 | 7904.877 | Ccr5 | 2.21E−05 |
Ccl9 | 24 | Pax6 | 7664.532 | Lpar3 | 2.21E−05 |
Ccr2 | 23 | Rhoc | 7643.579 | Gnai1 | 2.21E−05 |
Ccr3 | 22 | Dlg4 | 6747.256 | Ptafr | 2.21E−05 |
Igf1 | 21 | Actn1 | 6420.109 | Igf1 | 2.21E−05 |
Entpd1 | 20 | Gnai1 | 6334.163 | Ar | 2.21E−05 |
Rhoc | 20 | Igf1 | 5806.686 | Ccr3 | 2.20E−05 |
Dlg4 | 19 | Racgap1 | 5675.621 | Ccl9 | 2.20E−05 |
Entpd3 | 19 | Cyp2e1 | 5666.956 | P2ry12 | 2.20E−05 |
C3ar1 | 19 | Lpar3 | 5255.704 | Aplnr | 2.20E−05 |
Ar | 19 | Gpc6 | 5126.2 | C3ar1 | 2.20E−05 |
Dlg3 | 18 | Tgfb3 | 5025.73 | Htr2a | 2.20E−05 |
P2ry12 | 17 | H2-Aa | 4732.818 | Pparg | 2.20E−05 |
Htr1b | 17 | Pld4 | 4646.952 | Abca1 | 2.20E−05 |
Aplnr | 17 | Entpd1 | 4307.738 | Cd36 | 2.20E−05 |
Srebf1 | 17 | Htr2a | 4269.31 | Pf4 | 2.20E−05 |
Aurkb | 16 | Ctss | 4234.501 | Agtr1a | 2.20E−05 |