Table 2 KEGG pathway enrichment of all DEGs and modules
DEGs | Expression | Term | Count | p value | Genes |
|---|---|---|---|---|---|
All | Upregulated | mmu05150:Staphylococcus aureus infection | 13 | 1.16E−08 | C1qa, C3ar1, C1qb, Selp, Fcgr2b, C4b, Fcgr4, H2-aa, Cfd, H2-ea.-ps… |
|  |  | mmu05152:Tuberculosis | 16 | 1.64E−04 | Mrc1, Cd209a, Tlr1, Fcgr4, Ctss, Tlr9, Fcgr3, Vdr, Fcgr2b, Mapk13… |
|  |  | mmu03320:PPAR signaling pathway | 10 | 4.65E−04 | Lpl, Cd36, Cyp27a1, Pparg, Fabp4, Aqp7, Fabp7, Adipoq, Acsl6, Angptl4 |
|  |  | mmu04145:Phagosome | 15 | 4.89E−04 | Mrc1, H2-m9, Cd209a, Fcgr4, Ctss, Fcgr3, Cybb, Cd36, H2-m11, Fcgr2b… |
| Â | Â | mmu04610:Complement and coagulation cascades | 9 | 0.001 | C1qa, C3ar1, C1qb, C4b, Cd59a, F3, F8, Cfd, C1qc |
| Â | Â | mmu04620:Toll-like receptor signaling pathway | 10 | 0.002 | Cd86, Ccl3, Mapk13, Irf7, Tlr1, Il12a, Ticam2, Tlr7, Tlr8, Tlr9 |
|  |  | mmu04514:Cell adhesion molecules (CAMs) | 13 | 0.002 | Selp, H2-m9, Cadm1, Neo1, Ncam1, Siglec1, Cd86, H2-m11, H2-aa, Cd4… |
| Â | Â | mmu04614:Renin-angiotensin system | 6 | 0.003 | Ace, Agtr1a, Agt, Prcp, Cpa3, Enpep |
|  |  | mmu04080:Neuroactive ligand-receptor interaction | 18 | 0.004 | C3ar1, Thrb, Grik2, Lpar3, Vipr2, Ednra, P2ry13, Aplnr, P2ry6, Adrb2… |
| Â | Â | mmu04924:Renin secretion | 8 | 0.004 | Ednra, Ace, Adrb2, Agtr1a, Agt, Pde1a, Pde3b, Cacna1d |
| Â | Â | mmu05330:Allograft rejection | 7 | 0.005 | H2-m9, Cd86, H2-m11, Il12a, H2-aa, H2-t24, H2-ea.-ps |
| Â | Â | mmu04978:Mineral absorption | 6 | 0.006 | Vdr, Atp1b1, Mt2, Cybrd1, Slc40a1, Trf |
| Â | Â | mmu04940:Type I diabetes mellitus | 7 | 0.009 | H2-m9, Cd86, H2-m11, Il12a, H2-aa, H2-t24, H2-ea.-ps |
| Â | Â | mmu05142:Chagas disease (American trypanosomiasis) | 9 | 0.010 | C1qa, C1qb, Ace, Ccl3, Mapk13, Il12a, Smad3, C1qc, Tlr9 |
| Â | Â | mmu05332:Graft-versus-host disease | 6 | 0.017 | H2-m9, Cd86, H2-m11, H2-aa, H2-t24, H2-ea.-ps |
| Â | Â | mmu05133:Pertussis | 7 | 0.020 | C1qa, C1qb, C4b, Mapk13, Il12a, Ticam2, C1qc |
| Â | Â | mmu04310:Wnt signaling pathway | 10 | 0.021 | Fzd9, Dkk1, Sfrp1, Sfrp2, Fzd3, Camk2b, Fzd5, Daam2, Lrp5, Fzd6 |
|  |  | mmu04060:Cytokine-cytokine receptor interaction | 14 | 0.025 | Il1r2, Il1r1, Ccl3, Osmr, Ccl8, Pf4, Ccl7, Tnfsf10, Ccr5, Cxcl13… |
| Â | Â | mmu04960:Aldosterone-regulated sodium reabsorption | 5 | 0.027 | Atp1b1, Sgk1, Nr3c2, Igf1, Insr |
| Â | Â | mmu04380:Osteoclast differentiation | 9 | 0.029 | Il1r1, Cybb, Fcgr2b, Mapk13, Pparg, Fcgr4, Fhl2, Trem2, Fcgr3 |
| Â | Â | mmu04612:Antigen processing and presentation | 7 | 0.031 | H2-m9, H2-m11, H2-aa, Cd4, Ctss, H2-t24, H2-ea.-ps |
| Â | Â | mmu04640:Hematopoietic cell lineage | 7 | 0.034 | Il1r2, Il1r1, Cd36, Cd59a, Cd33, Csf3r, Cd4 |
| Â | Â | mmu05140:Leishmaniasis | 6 | 0.037 | Mapk13, Il12a, Fcgr4, H2-aa, H2-ea.-ps, Fcgr3 |
| Â | Â | mmu05144:Malaria | 5 | 0.049 | Selp, Cd36, Il12a, Thbs4, Tlr9 |
|  | Downregulated | mmu01130:Biosynthesis of antibiotics | 22 | 3.33E−06 | Cyp51, Ldhb, Shmt2, Msmo1, Pfkl, Hmgcr, Pafah2, Pgd, Pfkp, Fdps… |
|  |  | mmu01100:Metabolic pathways | 63 | 2.00E−04 | Ldhb, Sgms2, Alg1, Hmgcr, Cyp2s1, Pgd, Cyp2j6, Pgam1, Lss, Hlcs… |
|  |  | mmu00100:Steroid biosynthesis | 6 | 2.40E−04 | Cyp51, Msmo1, Sqle, Lss, Dhcr24, Fdft1 |
|  |  | mmu05412:Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 10 | 3.55E−04 | Itga5, Lmna, Itga11, Cacnb2, Sgcd, Actn1, Gja1, Lef1, Cacnb3, Sgcb |
| Â | Â | mmu00010:Glycolysis/Gluconeogenesis | 9 | 0.001 | Pgm2, Ldhb, Tpi1, Pfkl, Pfkp, Pgam1, Adh7, Aldh3b1, Eno1 |
| Â | Â | mmu00240:Pyrimidine metabolism | 10 | 0.005 | Pold4, Umps, Pole2, Pold1, Cda, Uck2, Dpyd, Polr3c, Nt5e, Polr2a |
|  |  | mmu00230:Purine metabolism | 13 | 0.011 | Ak4, Polr3c, Pfas, Polr2a, Pgm2, Pold4, Pole2, Pde1c, Pold1, Pde5a… |
| Â | Â | mmu05410:Hypertrophic cardiomyopathy (HCM) | 8 | 0.012 | Itga5, Tgfb3, Lmna, Itga11, Cacnb2, Sgcd, Cacnb3, Sgcb |
| Â | Â | mmu00030:Pentose phosphate pathway | 5 | 0.014 | Pgm2, Pfkl, Pgd, Pfkp, Dera |
| Â | Â | mmu05414:Dilated cardiomyopathy | 8 | 0.015 | Itga5, Tgfb3, Lmna, Itga11, Cacnb2, Sgcd, Cacnb3, Sgcb |
| Â | Â | mmu00670:One carbon pool by folate | 4 | 0.021 | Mthfd1, Shmt2, Aldh1l1, Mthfd1l |
| Â | Â | mmu00051:Fructose and mannose metabolism | 5 | 0.021 | Akr1b8, Tpi1, Pfkl, Pfkp, Pmm2 |
| Â | Â | mmu05217:Basal cell carcinoma | 6 | 0.029 | Wnt4, Fzd1, Lef1, Ptch2, Axin2, Gli3 |
| Â | Â | mmu01200:Carbon metabolism | 9 | 0.030 | Tpi1, Shmt2, Pfkl, Pgd, Phgdh, Pfkp, Esd, Pgam1, Eno1 |
| Â | Â | mmu00900:Terpenoid backbone biosynthesis | 4 | 0.034 | Hmgcr, Fdps, Hmgcs1, Idi1 |
| Â | Â | mmu01230:Biosynthesis of amino acids | 7 | 0.036 | Tpi1, Shmt2, Pfkl, Phgdh, Pfkp, Pgam1, Eno1 |
Module | 1 | mmu04062:Chemokine signaling pathway | 6 | 1.70E−05 | CCR5, CXCL13, GNAI1, CCR3, CCR2, CCL9 |
|  |  | mmu04080:Neuroactive ligand-receptor interaction | 6 | 1.00E−04 | C3AR1, APLNR, P2RY13, S1PR3, HTR1B, LPAR3 |
|  |  | mmu04060:Cytokine-cytokine receptor interaction | 4 | 8.90E−03 | CCR5, CXCL13, CCR3, CCR2 |
|  |  | mmu04024:cAMP signaling pathway | 3 | 4.80E−02 | HTR1B, GNAI1, HCAR1 |