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Table 2 Characteristics of included studies showing general intervention information

From: The efficacy of tranexamic acid using oral administration in total knee arthroplasty: a systematic review and meta-analysis

Studies (year) Dosage of TXA (mg) Surgical approach Transfusion criteria Postoperative anticoagulation Surgery Anesthesia DVT screening method Pneumatic tourniquet
Lee et al. (2017) [15] 3000 MP Hb < 80 g/L N/A Primary TKA General anesthesia Doppler ultrasonography Yes
Yuan et al. (2017) [14] N/A MP Hb < 80 g/L or anemia symptoms 10 mg/day rivaroxaban Primary TKA General anesthesia Doppler ultrasonography and chest computed tomography Yes
Perreault et al. (2017) [13] 3900 N/A Hb < 80 g/L or anemia symptoms N/A Primary TKA N/A N/A N/A
Zohar et al. (2004) [21] 3000 N/A Hematocrit < 28% 40 mg/day enoxaparin Primary TKA N/A Doppler ultrasound imaging and signs of lower limb DVT(swelling or increase in calf diameter) Yes
Alipour et al. (2013) [22] 3000 N/A N/A 40 mg/day enoxaparin Primary TKA Standard general anesthesia N/A Yes
Bradshaw et al. (2012) [20] 6000 MP Hb < 70 g/L or anemia symptoms 40 mg/day enoxaparin Primary TKA N/A N/A Yes
  1. TXA tranexamic acid, N/A not applicable, Hb hemoglobin, MP medial parapatellar approach, DVT deep vein thrombosis, TKA total knee arthroplasty