The efficacy of tranexamic acid using oral administration in total knee arthroplasty: a systematic review and meta-analysis

Table 1 The characteristics of included studies

Oral TXA group/control group
Studies (year)	Country	Cases	Ages (year)	Female gender (%)	Preoperative Hb (g/dL)	BMI (kg/m²)	Reference type	Preoperative diagnose	Preoperative thromboembolic events	Preoperative clotting disorder or anticoagulant therapy	QAS
Lee et al. (2017) [15]	China	94/95	70/68	67/69.55	13.6 ± 1.3/13.8 ± 1.2	27.7/28.4	RCT	N/A	None	None	6
Yuan et al. (2017) [14]	China	140/40	63.2/64.6	51.4/53.5	13.2 ± 0.8/13.2 ± 0.8	22.69/22.68	RCT	OA or RA	N/A	None	6
Perreault et al. (2017) [13]	USA	1049/866	66.1/66.2	62.4/58.2	14 ± 1.4/14 ± 1.4	N/A	RCS	N/A	None	N/A	6
Zohar et al. (2004) [21]	Israel	20/20	69/73	60/65	N/A	N/A	RCT	N/A	N/A	None	5
Alipour et al. (2013) [22]	Iran	27/26	68.6/63.11	59.3/56.7	N/A	28.9/29.3	RCT	OA or RA	None	None	6
Bradshaw et al. (2012) [20]	Australia	26/20	67.1/68.2	46.2/35	13.4 ± 2.5/13.8 ± 3	32.4/32.5	RCT	OA	None	None	6

TXA tranexamic acid, Hb hemoglobin, BMI body mass index, QAS quality assessment score, RCT randomized controlled trial, RCS retrospective cohort study, N/A not applicable, USA the United States of America, OA osteoarthritis, RA rheumatoid arthritis

ISSN: 1749-799X