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Table 1 The characteristics of included studies

From: The efficacy of tranexamic acid using oral administration in total knee arthroplasty: a systematic review and meta-analysis

Oral TXA group/control group
Studies (year) Country Cases Ages (year) Female gender (%) Preoperative Hb (g/dL) BMI (kg/m2) Reference type Preoperative diagnose Preoperative thromboembolic events Preoperative clotting disorder or anticoagulant therapy QAS
Lee et al. (2017) [15] China 94/95 70/68 67/69.55 13.6 ± 1.3/13.8 ± 1.2 27.7/28.4 RCT N/A None None 6
Yuan et al. (2017) [14] China 140/40 63.2/64.6 51.4/53.5 13.2 ± 0.8/13.2 ± 0.8 22.69/22.68 RCT OA or RA N/A None 6
Perreault et al. (2017) [13] USA 1049/866 66.1/66.2 62.4/58.2 14 ± 1.4/14 ± 1.4 N/A RCS N/A None N/A 6
Zohar et al. (2004) [21] Israel 20/20 69/73 60/65 N/A N/A RCT N/A N/A None 5
Alipour et al. (2013) [22] Iran 27/26 68.6/63.11 59.3/56.7 N/A 28.9/29.3 RCT OA or RA None None 6
Bradshaw et al. (2012) [20] Australia 26/20 67.1/68.2 46.2/35 13.4 ± 2.5/13.8 ± 3 32.4/32.5 RCT OA None None 6
  1. TXA tranexamic acid, Hb hemoglobin, BMI body mass index, QAS quality assessment score, RCT randomized controlled trial, RCS retrospective cohort study, N/A not applicable, USA the United States of America, OA osteoarthritis, RA rheumatoid arthritis