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Fig. 4 | Journal of Orthopaedic Surgery and Research

Fig. 4

From: Cortisol inhibits mTOR signaling in avascular necrosis of the femoral head

Fig. 4

Inhibition of mTOR by cortisol-induced cell apoptosis in BM-EPCs. a Application of COR (1.0 μM), DEX (1.0 μM), and rapamycin (RAPA, 10 μM) inducing apoptosis. b Application of COR and RAPA impacting on expression of apoptosis and mTOR-related genes. c Application of COR impacting on expression of DR5 and CHOP. d KD of CHOP impacting on DR5 expression and apoptotic indicator (n = 3, *P < 0.05, **P < 0.01)

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