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Table 1 The general characteristic of the included studies.

From: Intrathecal morphine versus femoral nerve block for pain control after total knee arthroplasty: a meta-analysis

Study

Country

FNB Group

Surgery

ITM Group

Outcomes

Follow-up

No. of patients

Method

Drug

No. of patients

Dose

Concomitant pain management

Frassanito 2010

Italy

26

SFNB

Ropivacaine 0.75% 25 ml

TKA

26

Hyperbaric bupivacaine 15 mg plus 0.1 mg of morphine sulphate

Paracetamol 1 g i.v. four times daily and intravenous. Ketorolac 30 mg 2 times every 24 h

1, 2, 3, 4

48 h

Mohamed 2016

Egypt

20

SFNB

Hyperbaric bupivacaine 15 mg

TKA

20

0.2 mg morphine

PCA with morphine

1, 2, 3, 4

3 month

Olive 2015

Australia

27

CFNB

20 ml bottle of 0.5% bupivacaine

TKA

28

0.5% bupivacaine 3.5 ml plus 0.175 mg morphine

0.5% bupivacaine 3.5 mL

1, 2, 3, 4

1 year

Sites 2004

USA

20

SFNB

40 mL of 0.5% ropivacaine with 75 mg of clonidine and 5 mg/mL of epinephrine

TKA

20

0.25 mg morphine and 15 mg hyperbaric bupivacaine

30 mg ketorolac IV every 6 h

1, 2, 3, 4

48 h

Tarkkila 1998

India

18

CFNB

0.25% bupivacaine at a rate of 0.1 mL kg 1 h 1

TKA

20

0.3 mg morphine mixed with bupivacaine

Oxycodone 0.1–0.14 mg/kg

1, 2, 3, 4

48 h

  1. FNB femoral nerve block, ITM intrathecal morphine, TKA total knee arthroplasty