Representative western blot and quantitative analysis of p-JNK, t-JNK, TNF-α, and β-actin in the kidney. There are 7, 7, 10 mice in CS, CS + vehicle, and CS + anti-HMGB1 antibody group, respectively (a, b). There are 7, 7, 10, 9 mice in the CS, CS + vehicle, CS + anti-TNF-α antibody, CS + SP600125 group, respectively (c, d). Results are described as mean ± SD. **p < 0.01, *p < 0.05, ns p > 0.05 versus the normal group.