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Table 2 Pathway enrichment summary iTRAQ data

From: A survey of proteomic biomarkers for heterotopic ossification in blood serum

Biological pathway

Pathway database

Ratio

Pathway proteins

Dataset proteins

p value

FDR

Extracellular matrix organization

R

0.0243

248

64

1.11E−16

1.30E−14

ECM-receptor interaction

K

0.0085

87

31

1.11E−16

1.30E−14

Response to elevated platelet cytosolic Ca2+

R

0.0081

83

45

1.11E−16

1.30E−14

Complement and coagulation cascades

K

0.0068

69

46

1.11E−16

1.30E−14

Beta1 integrin cell surface interactions

N

0.0065

66

27

1.11E−16

1.30E−14

Formation of fibrin clot (clotting cascade)

R

0.0038

39

24

1.11E−16

1.30E−14

Focal adhesion

K

0.0203

207

37

8.46E−12

8.46E−10

Staphylococcus aureus infection

K

0.0054

55

18

2.67E−10

2.35E−08

Beta3 integrin cell surface interactions

N

0.0042

43

16

4.32E−10

3.37E−08

L1CAM interactions

R

0.0077

79

20

2.15E−09

1.38E−07

  1. All proteins quantified in the iTRAQ experiment, regardless of the disease state, were uploaded in cytoscape via ReactomeFI application. A pathway enrichment analysis was executed for the entire reactome
  2. R Reactome, K KEGG, N NCI PID