TY - STD TI - Roberts DL, Dive C, Renehan AG. Biological mechanisms linking obesity and cancer risk: new perspectives. Annu Rev Med. p. 301–16. ID - ref1 ER - TY - STD TI - Guenther D, Schmidl S, Klatte TO, Widhalm HK, Omar M, Krettek C, et al. Overweight and obesity in hip and knee arthroplasty: evaluation of 6078 cases. World J Orthop. p. 137–44. ID - ref2 ER - TY - STD TI - Booth Jr. RE. Total knee arthroplasty in the obese patient: tips and quips. J Arthroplast. 2002:69–70. ID - ref3 ER - TY - STD TI - Park HS, Park JY, Yu R. Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6. Diabetes Res Clin Pr. 2005:29–35. ID - ref4 ER - TY - STD TI - Fasshauer M, Bluher M. Adipokines in health and disease. Trends Pharmacol Sci. p. 461–70. ID - ref5 ER - TY - STD TI - Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature. 1998:897–901. ID - ref6 ER - TY - STD TI - Santos-Alvarez J, Goberna R, Sanchez-Margalet V. Human leptin stimulates proliferation and activation of human circulating monocytes. Cell Immunol. 1999:6–11. ID - ref7 ER - TY - STD TI - Fantuzzi G, Faggioni R. Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukoc Biol. 2000:437–46. ID - ref8 ER - TY - STD TI - Nave H, Mueller G, Siegmund B, Jacobs R, Stroh T, Schueler U, et al. Resistance of Janus kinase-2 dependent leptin signaling in natural killer (NK) cells: a novel mechanism of NK cell dysfunction in diet-induced obesity. Endocrinology. 2008:3370–8. ID - ref9 ER - TY - STD TI - Wrann CD, Laue T, Hubner L, Kuhlmann S, Jacobs R, Goudeva L, et al. Short-term and long-term leptin exposure differentially affect human natural killer cell immune functions. Am J Physiol Endocrinol Metab. p. E108–16. ID - ref10 ER - TY - STD TI - Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (adipose most abundant gene transcript 1). Biochem Biophys Res Commun. 1996:556–9. ID - ref11 ER - TY - STD TI - Ouchi N, Kihara S, Funahashi T, Nakamura T, Nishida M, Kumada M, et al. Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue. Circulation. 2003:671–4. ID - ref12 ER - TY - STD TI - Simons PJ, van den Pangaart PS, Aerts JM, Boon L. Pro-inflammatory delipidizing cytokines reduce adiponectin secretion from human adipocytes without affecting adiponectin oligomerization. J Endocrinol. 2007:289–99. ID - ref13 ER - TY - STD TI - Vitale M, Bassini A, Secchiero P, Mirandola P, Ponti C, Zamai L, et al. NK-active cytokines IL-2, IL-12, and IL-15 selectively modulate specific protein kinase C (PKC) isoforms in primary human NK cells. Anat Rec. 2002:87–92. ID - ref14 ER - TY - STD TI - Lodolce JP, Burkett PR, Koka RM, Boone DL, Ma A. Regulation of lymphoid homeostasis by interleukin-15. Cytokine Growth Factor Rev. 2002:429–39. ID - ref15 ER - TY - STD TI - Ohradanova-Repic A, Machacek C, Fischer MB, Stockinger H. Differentiation of human monocytes and derived subsets of macrophages and dendritic cells by the HLDA10 monoclonal antibody panel. Clin Transl Immunol. p. e55. ID - ref16 ER - TY - STD TI - Ogawa K, Hirai M, Katsube T, Murayama M, Hamaguchi K, Shimakawa T, et al. Suppression of cellular immunity by surgical stress. Surgery. 2000:329–36. ID - ref17 ER - TY - STD TI - Hunter CA, Jones SA. IL-6 as a keystone cytokine in health and disease. Nat Immunol. p. 448–57. ID - ref18 ER - TY - STD TI - Matthies KM, Newman JL, Hodzic A, Wingett DG. Differential regulation of soluble and membrane CD40L proteins in T cells. Cell Immunol. 2006:47–58. ID - ref19 ER - TY - STD TI - Bisset LR, Lung TL, Kaelin M, Ludwig E, Dubs RW. Reference values for peripheral blood lymphocyte phenotypes applicable to the healthy adult population in Switzerland. Eur J Haematol. 2004:203–12. ID - ref20 ER - TY - STD TI - Santagostino A, Garbaccio G, Pistorio A, Bolis V, Camisasca G, Pagliaro P, et al. An Italian national multicenter study for the definition of reference ranges for normal values of peripheral blood lymphocyte subsets in healthy adults. Haematologica. 1999:499–504. ID - ref21 ER - TY - STD TI - Richmond SA, Fukuchi RK, Ezzat A, Schneider K, Schneider G, Emery CA. Are joint injury, sport activity, physical activity, obesity, or occupational activities predictors for osteoarthritis? A systematic review. J Orthop Sport Phys Ther. p. 515–B19. ID - ref22 ER - TY - STD TI - Wilson JA, Clark JJ. Obesity: impediment to wound healing. Crit Care Nurs Q. 2003:119–32. ID - ref23 ER - TY - STD TI - Klein S, Horowitz JF, Landt M, Goodrick SJ, Mohamed-Ali V, Coppack SW. Leptin production during early starvation in lean and obese women. Am J Physiol Endocrinol Metab. 2000:E280–4. ID - ref24 ER - TY - STD TI - Couillard C, Mauriege P, Prud’homme D, Nadeau A, Tremblay A, Bouchard C, et al. Plasma leptin concentrations: gender differences and associations with metabolic risk factors for cardiovascular disease. Diabetologia. 1997:1178–84. ID - ref25 ER - TY - STD TI - Batsis JA, Sahakyan KR, Singh P, Bartels SJ, Somers VK, Lopez-Jimenez F. Leptin, adiposity, and mortality: results from the National Health and Nutrition Examination Survey III, 1988 to 1994. Mayo Clin Proc. p. 481–91. ID - ref26 ER - TY - STD TI - Shi FD, Ljunggren HG, La Cava A, Van Kaer L. Organ-specific features of natural killer cells. Nat Rev Immunol. p. 658–71. ID - ref27 ER - TY - STD TI - Fogel LA, Yokoyama WM, French AR. Natural killer cells in human autoimmune disorders. Arthritis Res Ther. p. 216. ID - ref28 ER - TY - STD TI - Huss RS, Huddleston JI, Goodman SB, Butcher EC, Zabel BA. Synovial tissue-infiltrating natural killer cells in osteoarthritis and periprosthetic inflammation. Arthritis Rheum. p. 3799–805. ID - ref29 ER - TY - STD TI - Sokolove J, Lepus CM. Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations. Ther Adv Musculoskelet Dis. p. 77–94. ID - ref30 ER - TY - STD TI - De Lange-Brokaar BJ, Ioan-Facsinay A, van Osch GJ, Zuurmond AM, Schoones J, Toes RE, et al. Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review. Osteoarthr. Cartil. p. 1484–99. ID - ref31 ER - TY - STD TI - Brennan FM, Gibbons DL, Mitchell T, Cope AP, Maini RN, Feldmann M. Enhanced expression of tumor necrosis factor receptor mRNA and protein in mononuclear cells isolated from rheumatoid arthritis synovial joints. Eur J Immunol. 1992:1907–12. ID - ref32 ER -