Table 1 Characteristics of subjects in eligible studies
Author | Year | Location | Research time | Study register/abbreviation | Sample size | Average agea | Male/Female | Type of disease | Follow-up |
|---|---|---|---|---|---|---|---|---|---|
Yan Zhang [22] | 2013 | China | 2007–2008 | NA | 76 | 24.4 ± 1.7 | 44/32 | Enneking II-III | 5 years |
Neyssa M. Marina [23] | 2016 | International | 2005–2011 | EURAMOS-1 | 2260 (618) | 4–40 | 365/253 | High grade | 62–63 months |
Sophie Piperno-Neumann [24] | 2016 | France | 2007–2014 | OS2006 | 318 | 15.4 (5.8–50.9) | 179/136 | High grade | 3.9 years |
Stefan S. Bielack [25] | 2015 | International | 2005–2011 | EURAMOS-1 | 2260 (1041) | 14 (11–16) | 421/295 | High grade | 44 months |
Alessandra Longhi [26] | 2014 | Italy | 2007–2011 | EudraCT:2006-002676-18 | 20 | 34 (11–65) | 11//9 | Postrelapse | 73 months |
J.S. Whelan [27] | 2012 | Europe | 1982–2002 | EOI (BO02/80831) | 179 | 3–40 | 102/77 | High grade | 9.4 years |
EOI (BO03/80861) | 391 | 3–38 | 261/130 | High grade | 9.4 years | ||||
Hui Zhao [28] | 2010 | China | 2002–2007 | NA | 32 | 18.5 (7–68) | 16/16 | Lung metastasis | 60 months |
Alexander J. Chou [29] | 2009 | USA | 2001–2005 | CCG/POG (INT-0133) | 91 | <30 | 56/35 | High-grade intramedullary metastasis | 89 months |
Paul A. Meyers [30] | 2008 | USA | 2001–2005 | CCG/POG (INT-0133) | 662 | 13 (1–30) | 361/301 | High grade, Non-metastasis | 7.7 years |
Marie-Cecile Le Deley [31] | 2007 | France | 1994–2001 | SFOP-OS94 (NCT00180908) | 234 | 13.2 (3.1–19.5) | 131/103 | High grade | 77 months |
Paul A. Meyers [32] | 1998 | USA | 1986–1993 | MSKCC (T12) protocol | 73 | 15.8 (4.6–36.4) | 42/31 | High grade | 91.4 months |
Robert L. Souhami [33] | 1997 | International | 1986–1991 | EOI (T10) protocol | 407 | NA | 261/130 | High grade, Non-metastasis | 5.6 years |
Michael P. Link [34] | 1993 | International | 1982–1984 | MIOS | 36 | NA | NA | High grade, Non-metastasis | 4–8 years |
John H. Edmonson [35] | 1984 | USA | 1976–1980 | Mayo Clinic | 38 | 17 (9–62) | 24/14 | Postoperation | 31–74 months |
K. Winkler [36] | 1984 | Germany | 1979–1982 | COSS-80 | 116 | 14 (5–24) | 69/47 | High grade | 30 months |
F. Eilber [37] | 1987 | USA | 1981–1984 | NA | 112 | 15 (4–75) | 44/15 | Non-metastasis | 2 years |
D.R. Sweetnam [38] | 1986 | UK | 1975–1981 | NA | 194 | 1–40 | 111/83 | Lung metastasis | 26–94 months |
K. Winkler [39] | 1988 | Germany | 1982–1984 | COSS-82 | 125 | 14 | 73/52 | Osteosarcoma | 6 years |
Vivien H.C. Bramwell [40] | 1992 | Canada | 1983–1986 | EOI | 198 | NA | 114/84 | High grade | 5 years |
John C. Ivins [41] | 1976 | USA | 1974–1975 | Mayo Clinic | 26 | NA | NA | Osteosarcoma | 15 months |
C. Jasmin [42] | 1978 | France | 1976- | EORTC | 27 | 18 (9–28) | 13/14 | Osteosarcoma | 2 years |
Gilchrist GS [43] | 1978 | USA | NA | NA | 32 | NA | NA | Osteosarcoma | 753 days |
J.M.V. Burgers [44] | 1988 | Netherlands | 1978–1983 | EORTC-SIOP03 (20781) | 140 | 1–30 | 87/53 | Osteosarcoma | 5 years |