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Fig. 6 | Journal of Orthopaedic Surgery and Research

Fig. 6

From: Simvastatin protects ischemic spinal cord injury from cell death and cytotoxicity through decreasing oxidative stress: in vitro primary cultured rat spinal cord model under oxygen and glucose deprivation-reoxygenation conditions

Fig. 6

Effect of simvastatin on the motor neuron oxidative stress induced with ischemia–reperfusion. Oxidative stress of the motor neuron was assessed with DCFDA assay. OGD led to marked increase in DCF labeling of cells. Simvastatin treatment (0.1, 1, and 10 μM) effectively reduced DCF labeling following OGD. Values are represented as means ± SEM; asterisk denotes difference from control, and number sign denotes difference from OGD cells (n = 16; p < 0.05). OGD oxygen and glucose deprivation, DCFDA 2′,7′-dichlorofluorescein diacetate, DCF 2′,7′-dichlorofluorescein

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X