The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials

Shen, Longxiang; Yuan, Ting; Chen, Shengbao; Xie, Xuetao; Zhang, Changqing

doi:10.1186/s13018-017-0521-3

Journal of Orthopaedic Surgery and Research

Table 2 Details of PRP treatment protocols and control

From: The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials

	PRP						Control
Studies	Category^a	Preparation	Spinning	Activation	Injection dose, times, and intervals	Fresh/ frozen	Type	Injection dose, times, and intervals
Cerza et al.[9]	LP-PRP	ACP	Single	NR	5.5 mL, 4 times, weekly	Fresh	Hyalgan,	20 mg, 4 times, weekly
Duymus et al.[29]	LR-PRP	Ycellbio kit	Single	No	5 mL, 2 times, monthly	Fresh	Ostensil Plus, Ozone gas	40 mg, 1 time; 15 mL, 4 times, weekly
Filardo et al.[17]	LR-PRP	Custom	Double	CaCl₂	5 mL, 3 times, weekly	Frozen	Hyalubrix,	30 mg, 3 times, weekly
Forogh et al.[30]	LR-PRP^b	TUBEX kit	Double	CaCl₂	5 mL, 1 time	Fresh	Depo Medrol	40 mg, 1 time
Görmeli et al.[31]^c	LR-PRP	Custom	Double	CaCl₂	5 mL, 3 times, weekly	1Fresh/ 2Frozen	Orthovisc, Saline	30 mg, 3 times, weekly; NR, 3 times, weekly
Li et al.[10]	LR-PRP	Weigao kit	Double	CaCl₂	3.5 mL, 3 times, 3 weeks	Fresh	Sofast	2 mL, 3 times, 3 weeks
Montañez-Heredia et al.[35]	LP-PRP	Custom	Double	NR	NR, 3 times, 15 days	Frozen	Adant	NR, 3 times, 15 days
Patel et al.[11]^c	LP-PRP	Custom	Single	CaCl₂	8 mL, 2 times, 3 weeks	Fresh	Saline	8 mL, 1 time
Paterson et al.[32]	LR-PRP	Custom	Double	Ultraviolet	3 mL, 3 times, weekly	Fresh	Hylan G-F 20	3 mL, 3 times, weekly
Raeissadat et al.[33]	LR-PRP	Rooyagen kit	Double	No	4-6 mL, 2 times, 4 weeks	Fresh	Hyalgan	20 mg, 3 times, weekly
Sánchez et al.[13]	LP-PRP	PRGF-Endoret	Single	CaCl₂	8 mL, 3 times, weekly	Fresh	Euflexxa	NR, 3 times, weekly
Smith et al.[34]	LP-PRP	ACP	Single	NR	3-8 mL, 3 times, weekly	Fresh	Saline	3-8 mL, 3 times, weekly
Spaková et al.[14]	LR-PRP	Custom	Triple	No	3 mL, 3 times, weekly	Fresh	Erectus	NR, 3 times, weekly
Vaquerizo et al.[15]	LP-PRP	PRGF-Endoret	Single	CaCl₂	8 mL, 3 times, weekly	Fresh	Durolane	NR, 1 time

ACP autologous conditioned plasma, NR not reported, CaCl ₂ calcium chloride, Depo Medrol methylprednisolone acetate injectable suspension, PRGF plasma rich in growth factors
^a PRP was categorized into two types: LP-PRP (leukocyte-poor PRP) with the level of leukocytes below baseline and LR-PRP (leukocyte-rich PRP) with the level of leukocytes above baseline [45]
^bInformation was obtained from the authors through personal correspondence
^cIn a multi-arm trial, the group injected PRP more than once was regarded as an intervention group, and the data about the single-PRP injection group was not extracted

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ISSN: 1749-799X

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