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Table 2 Details of PRP treatment protocols and control

From: The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials

  PRP Control
Studies Categorya Preparation Spinning Activation Injection dose, times, and intervals Fresh/ frozen Type Injection dose, times, and intervals
Cerza et al.[9] LP-PRP ACP Single NR 5.5 mL, 4 times, weekly Fresh Hyalgan, 20 mg, 4 times, weekly
Duymus et al.[29] LR-PRP Ycellbio kit Single No 5 mL, 2 times, monthly Fresh Ostensil Plus,
Ozone gas 		40 mg, 1 time;
15 mL, 4 times, weekly
Filardo et al.[17] LR-PRP Custom Double CaCl2 5 mL, 3 times, weekly Frozen Hyalubrix, 30 mg, 3 times, weekly
Forogh et al.[30] LR-PRPb TUBEX kit Double CaCl2 5 mL, 1 time Fresh Depo Medrol 40 mg, 1 time
Görmeli et al.[31]c LR-PRP Custom Double CaCl2 5 mL, 3 times, weekly 1Fresh/
2Frozen 		Orthovisc,
Saline 		30 mg, 3 times, weekly;
NR, 3 times, weekly
Li et al.[10] LR-PRP Weigao kit Double CaCl2 3.5 mL, 3 times, 3 weeks Fresh Sofast 2 mL, 3 times, 3 weeks
Montañez-Heredia et al.[35] LP-PRP Custom Double NR NR, 3 times, 15 days Frozen Adant NR, 3 times, 15 days
Patel et al.[11]c LP-PRP Custom Single CaCl2 8 mL, 2 times, 3 weeks Fresh Saline 8 mL, 1 time
Paterson et al.[32] LR-PRP Custom Double Ultraviolet 3 mL, 3 times, weekly Fresh Hylan G-F 20 3 mL, 3 times, weekly
Raeissadat et al.[33] LR-PRP Rooyagen kit Double No 4-6 mL, 2 times, 4 weeks Fresh Hyalgan 20 mg, 3 times, weekly
Sánchez et al.[13] LP-PRP PRGF-Endoret Single CaCl2 8 mL, 3 times, weekly Fresh Euflexxa NR, 3 times, weekly
Smith et al.[34] LP-PRP ACP Single NR 3-8 mL, 3 times, weekly Fresh Saline 3-8 mL, 3 times, weekly
Spaková et al.[14] LR-PRP Custom Triple No 3 mL, 3 times, weekly Fresh Erectus NR, 3 times, weekly
Vaquerizo et al.[15] LP-PRP PRGF-Endoret Single CaCl2 8 mL, 3 times, weekly Fresh Durolane NR, 1 time
  1. ACP autologous conditioned plasma, NR not reported, CaCl 2 calcium chloride, Depo Medrol methylprednisolone acetate injectable suspension, PRGF plasma rich in growth factors
  2. a PRP was categorized into two types: LP-PRP (leukocyte-poor PRP) with the level of leukocytes below baseline and LR-PRP (leukocyte-rich PRP) with the level of leukocytes above baseline [45]
  3. bInformation was obtained from the authors through personal correspondence
  4. cIn a multi-arm trial, the group injected PRP more than once was regarded as an intervention group, and the data about the single-PRP injection group was not extracted
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