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Table 1 Characteristics of included studies

From: Comparison of the effectiveness and safety of topical versus intravenous tranexamic acid in primary total knee arthroplasty: a meta-analysis of randomized controlled trials

Authors Patients (T/I) Age (mean year) (C/I) Gender (F/M) Diagnosis Country Type of prosthesis Surgical protocol Pneumatic tourniquet Follow-up
Patel JN 2014 [31] 47/42 42/64.9 23/66 OA USA ns Con-TKA Yes 4.6
Maniar RN 2012 [30] 40/160 67.4/67.45 42/158 OA India Cemented CAS-TKA Yes 3
Seo JG 2013 [33] 50/50 67.5/66.8 11/89 OA Korea Cemented CAS-TKA Yes 2
Sarzaeem MM 2014 [32] 100/50 67.8/66.9 20/130 OA Iran Cemented Con-TKA Yes
Soni A 2014 [34] 40/40 69.45/69.05 36/44 OA India Cemented Con-TKA Yes 1.5
Tang Lian 2014 [29] 30/30 66.5/67.1 20/40 OA China ns Con-TKA Yes
Han WF 2014 [26] 50/50 ns 20/80 OA + RA China Cemented Con-TKA Yes 3 months
Aguilera X 2015 [24] 50/50 72.53/72.49 70/30 OA + RA + DKD Spain Cemented Con-TKA Yes 2
Digas G 2015 [25] 30/30 70/71 51/49 OA Germany Cemented Con-TKA Yes 25 days
Jiang Hua 2015 [28] 33/40 ns 54/19 DKD China ns Con-TKA Yes 7 days
Hou ZY 2015 [36] 20/20 67.36/67.02   OA + RA China Uncemented Con-TKA Yes 14 days
  1. NS not stated, T topical group, I intravenous group, OA osteoarthritis, RA rheumatoid arthritis, DKD degenerative knee disorders, Con-TKA conventional total knee arthroplasty, CAS-TKA computer-assisted total knee arthroplasty