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Table 3 Functional enrichment analysis for the 16 differentially expressed genes in the three significant modules

From: Screening for potential genes associated with bone overgrowth after mid-shaft femur fracture in a rat model

GO-ID

P value

corr P value

x

Description

Module A

 19934

1.47E−06

8.16E−04

2

cGMP-mediated signaling

 6916

7.95E−06

2.21E−03

3

Anti-apoptosis

 48856

6.61E−05

8.68E−03

5

Anatomical structure development

 43066

1.13E−04

8.68E−03

3

Negative regulation of apoptosis

 43069

1.17E−04

8.68E−03

3

Negative regulation of programmed cell death

 1936

1.19E−04

8.68E−03

2

Regulation of endothelial cell proliferation

 51239

1.26E−04

8.68E−03

4

Regulation of multicellular organismal process

 60548

1.31E−04

8.68E−03

3

Negative regulation of cell death

 10646

1.49E−04

8.68E−03

4

Regulation of cell communication

 32502

1.56E−04

8.68E−03

5

Developmental process

Module B

 6811

2.28E−07

1.94E−05

5

Ion transport

 6813

2.82E−06

1.20E−04

3

Potassium ion transport

 55085

9.85E−06

2.79E−04

4

Transmembrane transport

 15672

4.56E−05

9.69E−04

3

Monovalent inorganic cation transport

 51899

6.14E−05

1.01E−03

2

Membrane depolarization

 6810

7.76E−05

1.01E−03

5

Transport

 51234

8.34E−05

1.01E−03

5

Establishment of localization

 30001

1.42E−04

1.50E−03

3

Metal ion transport

 51179

1.67E−04

1.58E−03

5

Localization

 6812

2.86E−04

2.43E−03

3

Cation transport

Module C

 35023

3.21E−08

7.84E−06

4

Regulation of Rho protein signal transduction

 46578

6.27E−07

5.06E−05

4

Regulation of Ras protein signal transduction

 6917

8.14E−07

5.06E−05

4

Induction of apoptosis

 12502

8.29E−07

5.06E−05

4

Induction of programmed cell death

 51056

1.58E−06

7.73E−05

4

Regulation of small GTPase-mediated signal transduction

 8624

2.74E−06

1.12E−04

3

Induction of apoptosis by extracellular signals

 43065

6.29E−06

1.59E−04

4

Positive regulation of apoptosis

 43068

6.50E−06

1.59E−04

4

Positive regulation of programmed cell death

 6915

6.64E−06

1.59E−04

4

Apoptosis

 10942

7.15E−06

1.59E−04

4

Positive regulation of cell death