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Table 3 Subgroup analysis for VAS with rest at 12, 24, and 48 h

From: Combined femoral and sciatic nerve block versus femoral and local infiltration anesthesia for pain control after total knee arthroplasty: a meta-analysis of randomized controlled trials

Variables Studies (n) Patients (n) P value Incidence
MD (95% CI) Heterogeneity P value (I2) Model
VAS at 12 h
 SFNB 4 376 <0.001 −6.88 (−8.24,−5.47) 0.000 (86.1) Random
 CFNB 1 33 0.03 −14.4 (−27.37,−1.43)   
 Spinal anesthesia 2 275 <0.001 −5.76 (−7.25,−4.27) 0.348 (0.0) Fixed
 General anesthesia 3 134 <0.001 −15.81 (−19.86,−11.77) 0.566 (0.0) Fixed
VAS at 24 h
 SFNB 4 324 0.002 2.73 (0.98,4.47) 0.001 (86.3) Random
 CFNB 3 239 0.083 −3.91 (−8.32,0.51) 0.938 (0.0) Fixed
 Spinal anesthesia 2 275 0.145 5.79 (−2.01,13.59) 0.006 (87.0) Random
 General anesthesia 5 288 0.148 −2.84 (−6.69,1.01) 0.121 (45.2) Fixed
VAS at 48 h
 SFNB 2 275 0.000 −2.94 (−4.55,−1.33) 0.545 (0.0) Fixed
 CFNB 2 206 0.672 0.86 (−3.13,4.86) 0.281 (14.1) Fixed
 Spinal anesthesia 2 275 0.000 −2.94 (−4.55,−1.33) 0.545 (0.0) Fixed
 General anesthesia 2 206 0.672 0.86 (−3.13,4.86) 0.281 (14.1) Fixed
  1. SFNB single femoral nerve block, CFNB continuous femoral nerve block, VAS visual analogue scale, MD mean difference