Combined femoral and sciatic nerve block versus femoral and local infiltration anesthesia for pain control after total knee arthroplasty: a meta-analysis of randomized controlled trials

Table 3 Subgroup analysis for VAS with rest at 12, 24, and 48 h

Variables	Studies (n)	Patients (n)	P value	Incidence
Variables	Studies (n)	Patients (n)	P value	MD (95% CI)	Heterogeneity P value (I²)	Model
VAS at 12 h
SFNB	4	376	<0.001	−6.88 (−8.24,−5.47)	0.000 (86.1)	Random
CFNB	1	33	0.03	−14.4 (−27.37,−1.43)
Spinal anesthesia	2	275	<0.001	−5.76 (−7.25,−4.27)	0.348 (0.0)	Fixed
General anesthesia	3	134	<0.001	−15.81 (−19.86,−11.77)	0.566 (0.0)	Fixed
VAS at 24 h
SFNB	4	324	0.002	2.73 (0.98,4.47)	0.001 (86.3)	Random
CFNB	3	239	0.083	−3.91 (−8.32,0.51)	0.938 (0.0)	Fixed
Spinal anesthesia	2	275	0.145	5.79 (−2.01,13.59)	0.006 (87.0)	Random
General anesthesia	5	288	0.148	−2.84 (−6.69,1.01)	0.121 (45.2)	Fixed
VAS at 48 h
SFNB	2	275	0.000	−2.94 (−4.55,−1.33)	0.545 (0.0)	Fixed
CFNB	2	206	0.672	0.86 (−3.13,4.86)	0.281 (14.1)	Fixed
Spinal anesthesia	2	275	0.000	−2.94 (−4.55,−1.33)	0.545 (0.0)	Fixed
General anesthesia	2	206	0.672	0.86 (−3.13,4.86)	0.281 (14.1)	Fixed

SFNB single femoral nerve block, CFNB continuous femoral nerve block, VAS visual analogue scale, MD mean difference