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Table 2 Histology grading scale (modified from Mainil-Varlet et al. [37]) used in evaluation of medial menisco-tibial articulating tissues

From: Biological and functional evaluation of a novel pyrolytic carbon implant for the treatment of focal osteochondral defects in the medial femoral condyle: assessment in a canine model

Feature Score
I. Surface (0–3)
 Smooth and continuous
 Slight irregularities
 Moderate irregularities
 Discontinuous and irregular
3
2
1
0
II. Matrix (0–3)
 Hyaline
 Mixture of hyaline and fibrocartilage
 Fibrocartilage
 Fibrous tissue
3
2
1
0
III. Cell distribution (0–3)
 Columnar
 Mixed columnar and clusters
 Clusters
 Individual cells, disorganized
3
2
1
0
IV. Cell population viability (0–3)
 Intact–normal
 Intact–cellular changes
 Moderate disruption
 Severe disruption
3
2
1
0
V. Cartilage thinning/erosion, loss of stain (0–3)
 Normal
 Loss of staining
 Thinning
 Severe erosion
3
2
1
0
VI. Subchondral bone (0–3)
 Normal
 Active remodeling
 Severe bony changes
 Bone necrosis and/or granulation tissue
3
2
1
0
VII. Mineralization (0–3)
 Normal
 Slight changes
 Moderate changes
 Abnormal, inappropriate flocculation
3
2
1
0
VIII. Meniscus (0–3)
 Normal
 Slight changes
 Moderate disruption
 Severe disruption
3
2
1
0
Total score (0–24)