TY - JOUR AU - Minatani, Atsushi AU - Uchida, Kentaro AU - Inoue, Gen AU - Takano, Shotaro AU - Aikawa, Jun AU - Miyagi, Masayuki AU - Fujimaki, Hisako AU - Iwase, Dai AU - Onuma, Kenji AU - Matsumoto, Toshihide AU - Takaso, Masashi PY - 2016 DA - 2016/10/17 TI - Activation of calcitonin gene-related peptide signaling through the prostaglandin E2-EP1/EP2/EP4 receptor pathway in synovium of knee osteoarthritis patients JO - Journal of Orthopaedic Surgery and Research SP - 117 VL - 11 IS - 1 AB - Calcitonin gene-related peptide (CGRP) is a 37-amino-acid vasodilatory neuropeptide that binds to receptor activity-modifying protein 1 (RAMP1) and the calcitonin receptor-like receptor (CLR). Clinical and preclinical evidence suggests that CGRP is associated with hip and knee joint pain; however, the regulation mechanisms of CGRP/CGRP receptor signaling in synovial tissue are not fully understood. SN - 1749-799X UR - https://doi.org/10.1186/s13018-016-0460-4 DO - 10.1186/s13018-016-0460-4 ID - Minatani2016 ER -