Association between GDF5 +104T/C polymorphism and knee osteoarthritis in Caucasian and Asian populations: a meta-analysis based on case-control studies

Table 2 Meta-analysis of the association between GDF5 rs143383 polymorphism and OA susceptibility

Comparison	Ethnic group	Studies	Sample size		Test of association					Test of heterogeneity
Comparison	Ethnic group	Studies	OA	Control	OR	95 % CI		p value	Model	Q test	p value	I ² (%)
Allelic contrast	Overall	9	3319	4987	0.808	0.754	0.866	0.000	R	10.12	0.698	0
(T vs C allele)	Caucasian	4	1609	2940	0.872	0.794	0.957	0.004		1.43	0.518	0
	Asian	5	1710	2047	0.738	0.665	0.818	0.000		3.25	0.257	21
Dominant model	Overall	9	3319	4987	0.777	0.708	0.852	0.000	F	17.1	0.029	53.2
(TC + CC vs TT)	Caucasian	4	1609	2940	0.853	0.749	0.972	0.017		5.99	0.112	49.9
	Asian	5	1710	2047	0.706	0.619	0.806	0.000		7.16	0.128	44.1
Recessive model	Overall	9	3319	4987	0.723	0.623	0.839	0.000	R	6.66	0.574	0
(CC vs TC + TT)	Caucasian	4	1609	2940	0.797	0.659	0.965	0.02		1.60	0.659	0
	Asian	5	1710	2047	0.621	0.489	0.789	0.000		2.57	0.633	0
Additive model	Overall	9	3319	4987	0.648	0.552	0.760	0.000	R	5.84	0.665	0
(CC vs TT)	Caucasian	4	1609	2940	0.754	0.613	0.927	0.007		0.15	0.986	0
	Asian	5	1710	2047	0.518	0.402	0.668	0.000		0.69	0.953	0
Additive model	Overall	9	3319	4987	0.801	0.685	0.936	0.005	R	9.64	0.291	17
(CC vs TC)	Caucasian	4	1609	2940	0.84	0.688	1.026	0.088		4.49	0.213	33.2
	Asian	5	1710	2047	0.743	0.578	0.955	0.021		4.63	0.328	13.6

ISSN: 1749-799X