| n | (%) | Event no. | PY | Ratea | Crude HR (95 % CI) | Adjusted HR (95 % CI) | |||
---|---|---|---|---|---|---|---|---|---|---|
Total | 68,030 | Â | 1114 | 238,875 | 4.66 | Â | Â | |||
Age, year | ||||||||||
 20–29 | 53 | (0.08) | 9 | 260 | 34.57 | 30.9 (13.4–71.5)*** | 23.6 (10.2–54.7)*** | |||
 30–39 | 158 | (0.23) | 11 | 832 | 13.23 | 12.0 (5.43–26.4)*** | 8.52 (3.85–18.9)*** | |||
 40–49 | 499 | (0.73) | 25 | 2302 | 10.86 | 9.49 (4.93–18.3)*** | 6.90 (3.56–13.4)*** | |||
 50–59 | 1862 | (2.74) | 63 | 7908 | 7.97 | 6.65–3.73 (11.9)*** | 5.48 (3.06–9.82)*** | |||
 60–69 | 10,492 | (15.4) | 257 | 45,526 | 5.65 | 4.77 (2.79–8.17)*** | 4.35 (2.54–7.46)*** | |||
 70–79 | 26,868 | (39.5) | 458 | 101,757 | 4.50 | 3.59 (2.11–6.12)*** | 3.38 (1.99–5.76)*** | |||
 80–89 | 24,095 | (35.4) | 277 | 71,159 | 3.89 | 2.80 (1.64–4.80)*** | 2.73 (1.60–4.68)*** | |||
 ≥90 | 4003 | (5.88) | 14 | 9132 | 1.53 | 1.00 | 1.00 | |||
 Mean (SD) | 77.3 | (9.26) |  |  |  |  |  | |||
Gender | ||||||||||
 Women | 44,241 | (65.0) | 614 | 163,685 | 3.75 | 1.00 | 1.00 | |||
 Men | 23,789 | (35.0) | 500 | 75,190 | 6.65 | 1.69 (1.50–1.90)*** | 1.58 (1.40-1.78)*** | |||
Comorbidity | ||||||||||
 Diabetes | ||||||||||
  No | 51,877 | (76.3) | 861 | 191,518 | 4.50 | 1.00 |  | |||
  Yes | 16,153 | (23.7) | 253 | 47,357 | 5.34 | 1.09 (0.95–1.26) |  | |||
 Osteoporosis | ||||||||||
  No | 64,702 | (95.1) | 1057 | 228,211 | 4.63 | 1.00 |  | |||
  Yes | 3328 | (4.89) | 57 | 10,664 | 5.35 | 1.11 (0.85–1.45) |  | |||
 RA | ||||||||||
  No | 67,472 | (99.2) | 1099 | 236,796 | 4.64 | 1.00 |  | |||
  Yes | 558 | (0.82) | 15 | 2079 | 7.21 | 1.57 (0.94–2.61) |  | |||
 Cancer | ||||||||||
  No | 62,848 | (92.4) | 1038 | 226,145 | 4.59 | 1.00 |  | |||
  Yes | 5182 | (7.62) | 76 | 12,730 | 5.97 | 1.14 (0.90–1.44) |  | |||
 COPD |  | |||||||||
  No | 60,853 | (89.4) | 1008 | 219,410 | 4.59 | 1.00 |  | |||
  Yes | 7177 | (10.6) | 106 | 19,465 | 5.45 | 1.07 (0.88–1.31) |  | |||
 ESRD |  | |||||||||
  No | 66,073 | (97.1) | 1068 | 234,698 | 4.55 | 1.00 | 1.00 | |||
  Yes | 1957 | (2.88) | 46 | 4177 | 11.01 | 1.99 (1.48–2.68)*** | 1.74 (1.29–2.34)*** | |||
 SLE | ||||||||||
  No | 67,963 | (99.9) | 1112 | 238,679 | 4.66 | 1.00 |  | |||
  Yes | 67 | (0.10) | 2 | 196 | 10.19 | 2.03 (0.51–8.14) |  | |||
 Ankylosing spondylitis | ||||||||||
  No | 64,346 | (94.6) | 1059 | 228,091 | 4.64 | 1.00 |  | |||
  Yes | 3684 | (5.42) | 55 | 10,785 | 5.10 | 1.02 (0.78–1.34) |  | |||
 Extrinsic asthma | ||||||||||
  No | 67,850 | (99.7) | 1112 | 238,299 | 4.67 | 1.00 |  | |||
  Yes | 180 | (0.26) | 2 | 576 | 3.47 | 0.72 (0.18–2.89) |  | |||
 HIV | ||||||||||
  No | 68,022 | (99.9) | 1114 | 238,853 | 4.66 | 1.00 |  | |||
  Yes | 8 | (0.01) | 0 | 22 | 0.00 | –– |  | |||
 Atherosclerosis | ||||||||||
  No | 67,550 | (99.3) | 1106 | 237,521 | 4.66 | 1.00 |  | |||
  Yes | 480 | (0.71) | 8 | 1355 | 5.91 | 1.17 (0.58–2.35) |  | |||
 Psoriasis | ||||||||||
  No | 67,898 | (99.8) | 1112 | 238,505 | 4.66 | 1.00 |  | |||
  Yes | 132 | (0.19) | 2 | 370 | 5.40 | 1.09 (0.27–4.36) |  | |||
 Viral hepatitis | ||||||||||
  No | 66,212 | (97.3) | 1080 | 234,523 | 4.61 | 1.00 | 1.00 | |||
  Yes | 1818 | (2.67) | 34 | 4353 | 7.81 | 1.46 (1.04–2.06)* | 1.30 (0.92–1.83) | |||
 Depression | ||||||||||
  No | 66,091 | (97.2) | 1081 | 232,874 | 4.64 | 1.00 |  | |||
  Yes | 1939 | (2.85) | 33 | 6002 | 5.50 | 1.12 (0.79–1.59) |  | |||
 Schizophrenia | ||||||||||
  No | 67,399 | (99.1) | 1088 | 236,468 | 4.60 | 1.00 | 1.00 | |||
  Yes | 631 | (0.93) | 26 | 2408 | 10.80 | 2.43 (1.65–3.58)*** | 1.88 (1.26–2.79)** | |||
 Heart failure | ||||||||||
  No | 62,500 | (91.9) | 1035 | 22,478 | 4.59 | 1.00 |  | |||
  Yes | 5530 | (8.13) | 79 | 13,397 | 5.90 | 1.11 (0.89–1.40) |  | |||
 UTI | ||||||||||
  No | 55,877 | (82.1) | 936 | 204,007 | 4.59 | 1.00 |  | |||
  Yes | 12,153 | (17.9) | 178 | 34,869 | 5.10 | 1.2 (0.87–1.19) |  | |||
 Ischemic heart disease | ||||||||||
  No | 55,681 | (81.9) | 915 | 203,038 | 4.51 | 1.00 |  | |||
  Yes | 12,349 | (81.9) | 199 | 35,837 | 5.55 | 1.13 (0.97–1.32) |  | |||
 Dementia | ||||||||||
  No | 65,633 | (96.5) | 1091 | 231,906 | 4.70 | 1.00 | 1.00 | |||
  Yes | 2397 | (3.52) | 23 | 6969 | 3.30 | 0.65 (0.43–0.98)* | 0.71 (0.47–1.07) |