Fig. 4

Histological observation of fibroblasts in the epidural scar tissue of the laminectomy defect areas in groups treated with RAPA of 0.2 mg/ml (a), 0.1 mg/ml (b), 0.05 mg/ml (c) or the control group(d). The number of fibroblasts in the 0.2 mg/ml RAPA group and 0.1 mg/ml RAPA group was lower than in the control group, but there was no significant difference between the 0.05 mg/ml RAPA group and control group. The fibroblast count in the 0.2 mg/ml RAPA group was also lower than those of the other RAPA groups. The sections were stained with haematoxylin–eosin and the magnification is ×400