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Table 1 Characteristics of included studies

From: Cross-linked versus conventional polyethylene for total knee arthroplasty: a meta-analysis

Study

Study design

Group

Simple size

Age (year)

Gender (M/F)

BMI

Manufacture

Devices information

Follow-up

Lost follow-up

Hodrick et al. 2008 [3]

CCT

XLPE

100

67 ± 12

42/58

NS

Compression-molded polyethylene sterilized with ethylene oxide gas preheated at 125°m and irradiated with a dose 9.5 Mrad (95 kGy) through an electron beam.

Natural knee II system (Zimmer)

Mean 75 months

18

 

CP

100

70 ± 12

40/60

NS

Compression-molded polyethylene, which was gamma-irradiated in nitrogen.

Mean 82 months

17

Minoda et al. 2009 [21]

CCT

XLPE

89

70.3 ± 8.9

19/70

NS

GUR 1050 UHMWPE bar cross-linked by subjection of 65 kGy of electron beam with thermal treatment above melting point, and were sterilized by gas plasma.

NexGen CR. Zimmer)

2 years

0

 

CP

113

71.1 ± 7.3

20/93

NS

Net-shape molding of GUR 1050 resin and sterilized by gamma radiation in nitrogen at a dose of 37 kGy.

0

Lachiewicz and Soileau 2015 [19]

RCT

XLPE

110

68 ± 10

35/75

31

Electron beam, 6.5 CGy irradiated in nitrogen, remelted to quench the free radicals; then sterilized by ethylene oxide

Zimmer, Inc, Warsaw, IN, USA

Minimum 2 years

14

 

CP

122

70 ± 10

37/85

31

Gamma-irradiated in nitrogen

 

21

Meneghini et al. 2015 [20]

PCT

XLPE

64

63.8

18/29

31.5

GUR 1020 UHMWPE and cross-linking was performed with a cycled process of gamma-irradiation at 30 kGy followed by annealing at 130 °C for 8 h, which was repeated 3 times sequentially

Posterior-substituting single-radius design (Triathlon; Stryker, Mahwah, NJ)

5.2 years (range, 4.3–5.8 years).

10

 

CP

50

67.3

12/25

31.1

Compression-molded GU 1020 UHMWPE, packed in nitrogen and gamma-irradiated at 30 kGy.

5.5 years (range, 4.8–7.4 years)

Kim and Park 2014 [17]

RCT

XLPE

308

60.3 ± 4.3

20/288

29.1

Machined from GUR1050 resin bar.

NexGen Legacy Posterior-stabilized (LPS)-Flex total knee prosthesis (Zimmer,Warsaw, Indiana)

59 years (range, 5–6.8 years)

0

CP

308

60.3 ± 4.3

20/288

29.1

Machined from GUR1050 resin bar, cross-linked by a 65-kGy electron beam

0

Kindsfater et al. 2015 [18]

RCT

XLPE

477

66.4 ± 8.5

35.4 %/64.6 %

32.6

NS

P.F.C. Sigma fixed-bearing knees (DePuy Synthes Joint Reconstruction, Warsaw, IN).

5-year

298

CP

449

66.3 ± 8.5

35.4 %/64.6 %

33.2

NS

260