Fig. 1
From: Animal models of osteoarthritis: classification, update, and measurement of outcomes
Signaling pathways and structural changes in the development of osteoarthritis with showing the normal joint (a) and showing the diseased joint (b). ADAMTS a disintegrin and metalloproteinase with thrombospondin-like motifs, I interleukin, MMP matrix metalloproteinase, TNF tumor necrosis factor, IFN interferon, IGF insulin-like growth factor, TGF transforming growth factor, VEGF vascular endothelial growth factor; taken with permission from Glyn-Jones et al. [33]