Skip to main content

Table 3 Immunohistochemical analysis on the femur articular cartilages

From: Adipose-derived mesenchymal stem cells and platelet-rich plasma synergistically ameliorate the surgical-induced osteoarthritis in Beagle dogs

Cell numbers (cells/mm2)

Sham

Control

MSC

PRP

MP

BrdU+

144.17ā€‰Ā±ā€‰47.83

9.00ā€‰Ā±ā€‰2.83f

55.00ā€‰Ā±ā€‰17.34fg

77.17ā€‰Ā±ā€‰20.36g

129.67ā€‰Ā±ā€‰31.39fghi

IL-1Ī²+

14.67ā€‰Ā±ā€‰4.18

140.50ā€‰Ā±ā€‰16.69a

50.83ā€‰Ā±ā€‰15.77ab

44.50ā€‰Ā±ā€‰13.66ab

23.50ā€‰Ā±ā€‰7.87bcd

TNF-Ī±+

5.50ā€‰Ā±ā€‰4.09

103.00ā€‰Ā±ā€‰18.70f

55.33ā€‰Ā±ā€‰18.91fg

38.00ā€‰Ā±ā€‰10.16fg

13.83ā€‰Ā±ā€‰3.66ghi

COX-2+

16.33ā€‰Ā±ā€‰2.73

102.67ā€‰Ā±ā€‰22.57f

65.50ā€‰Ā±ā€‰10.21fg

44.50ā€‰Ā±ā€‰10.21fg

23.67ā€‰Ā±ā€‰6.92ghi

iNOS+

57.83ā€‰Ā±ā€‰15.82

196.67ā€‰Ā±ā€‰42.57a

106.50ā€‰Ā±ā€‰17.60ab

66.17ā€‰Ā±ā€‰10.53b

40.33ā€‰Ā±ā€‰12.40bce

Caspase-3+

16.50ā€‰Ā±ā€‰8.87

80.33ā€‰Ā±ā€‰11.22a

52.17ā€‰Ā±ā€‰12.62ab

46.17ā€‰Ā±ā€‰11.86ab

18.00ā€‰Ā±ā€‰8.46bcd

PARP+

30.00ā€‰Ā±ā€‰11.92

101.17ā€‰Ā±ā€‰21.64a

64.17ā€‰Ā±ā€‰14.63ab

54.50ā€‰Ā±ā€‰13.16ab

32.50ā€‰Ā±ā€‰10.31bce

IFN-Ī³+

5.33ā€‰Ā±ā€‰3.27

88.33ā€‰Ā±ā€‰13.35a

47.17ā€‰Ā±ā€‰11.51ab

31.17ā€‰Ā±ā€‰15.28ab

12.50ā€‰Ā±ā€‰2.88bcd

  1. Values are expressed as meanā€‰Ā±ā€‰SD of six dogs
  2. MSC mesenchymal stem cells, PRP platelet-rich plasma, MP MSC and PRP co-treatment
  3. a pā€‰<ā€‰0.01 as compared with sham control by LSD test
  4. b pā€‰<ā€‰0.01 as compared with control by LSD test
  5. c pā€‰<ā€‰0.01 as compared with MSC treated group by LSD test
  6. d pā€‰<ā€‰0.01 as compared with PRP treated group by LSD test
  7. e pā€‰<ā€‰0.05 as compared with PRP treated group by LSD test
  8. f pā€‰<ā€‰0.01 as compared with sham control by MW test
  9. g pā€‰<ā€‰0.01 as compared with control by MW test
  10. h pā€‰<ā€‰0.01 as compared with MSC treated group by MW test
  11. i pā€‰<ā€‰0.01 as compared with PRP treated group by MW test