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Fig. 7 | Journal of Orthopaedic Surgery and Research

Fig. 7

From: IL-1β promotes ADAMTS enzyme-mediated aggrecan degradation through NF-κB in human intervertebral disc

Fig. 7

Regulation of ADAMTS-4 and ADAMTS-5 expression by NF-κB. a qRT-PCR analysis of cells transduced with control lentivirus LV-shC and LV-shp65. b, c qRT-PCR analysis of ADAMTS-4, ADAMTS-5, and aggrecan in human NP cells infected with LV-shC and LV-shp65. Note that the IL-1β-dependent increase in ADAMTS-4, ADAMTS-5, and aggrecan levels is significantly increased by suppression of the component of the NF-κB-p65 signaling pathway. Data are expressed as mean ± SD from six independent experiments. *P < 0.05 vs. IL-1β alone; # P < 0.05 vs. control

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