Fig. 5

Modulation of IL-1β-dependent expression of ADAMTS-4 and ADAMTS-5 expression by NF-κB signaling in human NP cells. a Western blot analysis of p65 nucleoproteins after treatment of NP cells with IL-1β. b Western blot analysis indicates that treatment with NF-κB inhibitor completely abolished ADAMTS-4 and ADAMTS-5 protein induction by IL-1β and the level of aggrecan was significantly increased. Data are expressed as mean ± SD from three independent experiments