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Fig. 3 | Journal of Orthopaedic Surgery and Research

Fig. 3

From: IL-1β promotes ADAMTS enzyme-mediated aggrecan degradation through NF-κB in human intervertebral disc

Fig. 3

Expression and cytokine dependency of ADAMTS-4, ADAMTS-5, and aggrecan in human NP cells. a, b RT-PCR analysis of ADAMTS-4 and ADAMTS-5 expression by human NP cells treated with IL-1β. There was a dose-dependent increase in ADAMTS-4 and ADAMTS-5 mRNA expression by the cytokine treatment. c Treatment of human NP cells with IL-1β resulted in a significant decrease of aggrecan. Data are expressed as mean ± SD from six independent experiments. *P < 0.05 vs. control

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