Fig. 2
From: Transmission of ER stress response by ATF6 promotes endochondral bone growth
Expression of ATF6 in the growth plate chondrocytes in vivo. ATF6 immunohistochemistry in tibial growth plates of postcoital day 15.5 mouse embryo (E15.5; b, g), postcoital day 17.5 mouse embryo (E17.5; c, h), newborn (d, i) and day 10 old (e, j). Microphotographs are shown of sections stained with anti-ATF6 antibody (brown) and counterstained with hematoxylin (blue). Immunostaining reveals positive nuclear staining in the entire chondrogenic developmental stages in both proliferating and hypertrophic zones, and the scale bars represent 100 μm. The red arrow is protein ATF6. NC (a, f) negative control, P proliferating chondrocytes, H hypertrophic chondrocytes, M bone metaphysis