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Table 3 The top five terms of Gene Ontology category analysis for the down-regulated differentially expressed genes

From: Identification of genes associated with methotrexate resistance in methotrexate-resistant osteosarcoma cell lines

Category Term Name Counts Gene symbol p value
Biological process GO:0000226 Microtubule cytoskeleton organization 46 AURKA, AURKB, CCNB1 CDK1, CENPA, FBXO5, … 0
GO:0000278 Mitotic cell cycle 119 AURKA, AURKB, CCNE2, CDK1, CENPA, CENPH, FBXO5, RRM2, … 0
GO:0000280 Nuclear division 68 AURKA, AURKB, CCNB1, CCNB2, CENPE, … 0
  GO:0006996 Organelle organization 164 AURKA, AURKB, CCNB1, CCNB2, CDK1, CENPA, CENPE, CENPH, … 0
  GO:0007017 Microtubule-based process 59 AURKA, AURKB, CCNB1, CDK1, CENPA, FBXO5, … 0
Molecular function GO:0005515 Protein binding 334 AURKA, AURKB, CCNB1, CCNB2, CCNE2, CDK1, HMGB2, … 8.15E−13
GO:0000166 Nucleotide binding 122 AURKA, AURKB, CDK1, CENPE, EEF1A1, … 1.32E−07
GO:1901265 Nucleoside phosphate binding 122 AURKA, AURKB, CDK1, CENPE, EEF1A1, … 1.35E−07
GO:0036094 Small molecule binding 127 AURKA, AURKB, CDK1, CENPE, EEF1A1, … 2.24E−07
GO:0008017 Microtubule binding 19 CENPE, KIF14, KIF15, PLK1, … 8.25E−07
Cellular components GO:0000775 Chromosome, centromeric region 37 AURKB, BUB1, CCNB1, CENPA, CENPH, … 0
GO:0000776 Kinetochore 29 CCNB1, CENPA, CENPE CENPH, KIF22, … 0
GO:0000777 Condensed chromosome kinetochore 27 CCNB1, CENPA, CENPE CENPH, KIF2C, … 0
GO:0000779 Condensed chromosome, centromeric region 28 AURKB, CCNB1, CENPA, CENPE, CENPH, … 0
  GO:0000793 Condensed chromosome 42 AURKB, CCNB1, CENPA, CENPH, KIF2C, … 0