Table 3 The top five terms of Gene Ontology category analysis for the down-regulated differentially expressed genes
Category | Term | Name | Counts | Gene symbol | p value |
|---|---|---|---|---|---|
Biological process | GO:0000226 | Microtubule cytoskeleton organization | 46 | AURKA, AURKB, CCNB1 CDK1, CENPA, FBXO5, … | 0 |
GO:0000278 | Mitotic cell cycle | 119 | AURKA, AURKB, CCNE2, CDK1, CENPA, CENPH, FBXO5, RRM2, … | 0 | |
GO:0000280 | Nuclear division | 68 | AURKA, AURKB, CCNB1, CCNB2, CENPE, … | 0 | |
|  | GO:0006996 | Organelle organization | 164 | AURKA, AURKB, CCNB1, CCNB2, CDK1, CENPA, CENPE, CENPH, … | 0 |
|  | GO:0007017 | Microtubule-based process | 59 | AURKA, AURKB, CCNB1, CDK1, CENPA, FBXO5, … | 0 |
Molecular function | GO:0005515 | Protein binding | 334 | AURKA, AURKB, CCNB1, CCNB2, CCNE2, CDK1, HMGB2, … | 8.15E−13 |
GO:0000166 | Nucleotide binding | 122 | AURKA, AURKB, CDK1, CENPE, EEF1A1, … | 1.32E−07 | |
GO:1901265 | Nucleoside phosphate binding | 122 | AURKA, AURKB, CDK1, CENPE, EEF1A1, … | 1.35E−07 | |
GO:0036094 | Small molecule binding | 127 | AURKA, AURKB, CDK1, CENPE, EEF1A1, … | 2.24E−07 | |
GO:0008017 | Microtubule binding | 19 | CENPE, KIF14, KIF15, PLK1, … | 8.25E−07 | |
Cellular components | GO:0000775 | Chromosome, centromeric region | 37 | AURKB, BUB1, CCNB1, CENPA, CENPH, … | 0 |
GO:0000776 | Kinetochore | 29 | CCNB1, CENPA, CENPE CENPH, KIF22, … | 0 | |
GO:0000777 | Condensed chromosome kinetochore | 27 | CCNB1, CENPA, CENPE CENPH, KIF2C, … | 0 | |
GO:0000779 | Condensed chromosome, centromeric region | 28 | AURKB, CCNB1, CENPA, CENPE, CENPH, … | 0 | |
|  | GO:0000793 | Condensed chromosome | 42 | AURKB, CCNB1, CENPA, CENPH, KIF2C, … | 0 |