Fig. 4

18F-FDG PET/CT scan images of a successfully treated rabbit with experimental tibial staphylococcal osteomyelitis. Sagittal images of the tibia of a rabbit demonstrating (top) increased tracer uptake (SUVmax = 4.8) at the area of osteomyelitis in the upper third of the tibia extending to the adjacent soft tissues (arrow) before the initiation of treatment and (bottom) physiologic tracer activity in the tibia of the same rabbit after 6 weeks of treatment with daptomycin. The animal was euthanized immediately after the 18F-FDG PET/CT scan, and bone cultures and histology were negative for infection. Note: On the left are the PET images and on the right the fused PET/CT images