Table 1 Histological scoring for in vivo rabbit study

2 weeks

21.3 ± 0.6

20.3 ± 0.6

20.0 ± 1.0

17.7 ± 1.5^a,b

4 weeks

18.3 ± 0.6

20.0 ± 1.0

15.7 ± 2.1^b

13.7 ± 0.6^a,b

8 weeks

18.7 ± 0.6

19.7 ± 0.6

14.0 ± 1.0^a,b

11.0 ± 1.0^a,b,c

12 weeks

19.0 ± 2.0

14.7 ± 1.5^a

12.0 ± 1.0^a

9.7 ± 2.3^a,b