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Table 8 Combined cartilage and bone repair score results (from ICRS II-2010 and O’Driscoll et al.)

From: Osteochondral regeneration with a novel aragonite-hyaluronate biphasic scaffold: up to 12-month follow-up study in a goat model

Time period Group Nature of predominant tissue Structural characteristics Freedom from cellular changes of degeneration Freedom from degenerative changes in adjacent cartilage Total performance score Collagen type II Collagen type I Overall assessment
Tissue morphology Safranin-O staining of the matrix Surface regularity Structural integrity Thickness Bonding to the adjacent cartilage Basal integration Formation of a tidemark xSubchondral bone abnormalities/marrow fibrosis Cancellous bone regeneration Abnormal calcification/ossification (cartilage tissue) Hypocellularity Chondrocyte clustering
6 months Agili-C Mean 3.4 2.4 2.4 1.6 1.9 2.0 4.0 2.6 2.6 2.3 0.0 2.9 0.4 2.6 31.0 3.0 0.4 3.4
SD 0.9 0.7 0.5 0.5 0.3 0.0 0.0 0.5 1.0 0.7 0.0 0.3 0.5 0.5 4.1 0.0 0.7 0.9
Empty defect control Mean 2.0 2.0 1.7 1.0 0.7 1.0 1.3 1.0 0.0 1.3 0.0 2.0 0.7 1.7 16.3 2.0 1.2 2.0
SD 1.6 0.8 1.2 0.8 0.5 0.8 1.9 1.4 0.0 0.5 0.0 1.4 0.5 1.2 11.8 1.3 1.0 1.6
12 months Agili-C Mean 3.7 2.9 2.0 1.7 1.6 2.0 4.0 2.9 2.6 3.6 0.0 2.4 1.0 2.7 33.0 2.9 0.1 3.9
SD 0.7 0.3 0.8 0.5 0.7 0.0 0.0 0.3 1.0 0.7 0.0 0.7 0.0 0.7 5.5 0.3 0.3 0.3
Empty defect control Mean 1.7 2.3 0.3 0.7 1.0 1.7 2.3 1.7 0.0 1.3 0.3 2.0 1.3 1.3 18.0 1.7 0.3 1.0
SD 0.5 0.9 0.5 0.5 0.8 0.5 1.2 1.2 0.0 0.5 0.5 0.8 0.5 1.2 8.3 1.2 0.5 0.8
  1. SD standard deviation