Table 8 Combined cartilage and bone repair score results (from ICRS II-2010 and O’Driscoll et al.)
Time period | Group | Nature of predominant tissue | Structural characteristics | Freedom from cellular changes of degeneration | Freedom from degenerative changes in adjacent cartilage | Total performance score | Collagen type II | Collagen type I | Overall assessment | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tissue morphology | Safranin-O staining of the matrix | Surface regularity | Structural integrity | Thickness | Bonding to the adjacent cartilage | Basal integration | Formation of a tidemark | xSubchondral bone abnormalities/marrow fibrosis | Cancellous bone regeneration | Abnormal calcification/ossification (cartilage tissue) | Hypocellularity | Chondrocyte clustering | ||||||||
6 months | Agili-C | Mean | 3.4 | 2.4 | 2.4 | 1.6 | 1.9 | 2.0 | 4.0 | 2.6 | 2.6 | 2.3 | 0.0 | 2.9 | 0.4 | 2.6 | 31.0 | 3.0 | 0.4 | 3.4 |
SD | 0.9 | 0.7 | 0.5 | 0.5 | 0.3 | 0.0 | 0.0 | 0.5 | 1.0 | 0.7 | 0.0 | 0.3 | 0.5 | 0.5 | 4.1 | 0.0 | 0.7 | 0.9 | ||
Empty defect control | Mean | 2.0 | 2.0 | 1.7 | 1.0 | 0.7 | 1.0 | 1.3 | 1.0 | 0.0 | 1.3 | 0.0 | 2.0 | 0.7 | 1.7 | 16.3 | 2.0 | 1.2 | 2.0 | |
SD | 1.6 | 0.8 | 1.2 | 0.8 | 0.5 | 0.8 | 1.9 | 1.4 | 0.0 | 0.5 | 0.0 | 1.4 | 0.5 | 1.2 | 11.8 | 1.3 | 1.0 | 1.6 | ||
12 months | Agili-C | Mean | 3.7 | 2.9 | 2.0 | 1.7 | 1.6 | 2.0 | 4.0 | 2.9 | 2.6 | 3.6 | 0.0 | 2.4 | 1.0 | 2.7 | 33.0 | 2.9 | 0.1 | 3.9 |
SD | 0.7 | 0.3 | 0.8 | 0.5 | 0.7 | 0.0 | 0.0 | 0.3 | 1.0 | 0.7 | 0.0 | 0.7 | 0.0 | 0.7 | 5.5 | 0.3 | 0.3 | 0.3 | ||
Empty defect control | Mean | 1.7 | 2.3 | 0.3 | 0.7 | 1.0 | 1.7 | 2.3 | 1.7 | 0.0 | 1.3 | 0.3 | 2.0 | 1.3 | 1.3 | 18.0 | 1.7 | 0.3 | 1.0 | |
SD | 0.5 | 0.9 | 0.5 | 0.5 | 0.8 | 0.5 | 1.2 | 1.2 | 0.0 | 0.5 | 0.5 | 0.8 | 0.5 | 1.2 | 8.3 | 1.2 | 0.5 | 0.8 | ||