From: Do bisphosphonates affect bone healing? A meta-analysis of randomized controlled trials
Study (country) years | Gender (M/F) | Number of patients (bisphosphonate/control) | Mean age (years) | Selection criteria | Intervention (calcium and/or vitamin D) | Time of starting treatment | Fracture healing criteria | Outcome measured |
---|---|---|---|---|---|---|---|---|
van der Poest et al. (Netherlands) 2000 [7] | F | 18/17 | 65.7 | Distal forearm fractures, T-score ≤ 2 | 10 mg alendronate + 500 mg calcium vs. placebo + 500 mg calcium | 2–4 weeks after fracture | Radiographs and functional outcome | BMD, bone markers, fracture healing |
Adolphson et al. (Sweden) 2000 [5] | F | 16/16 | 62 | Displaced Colles' fracture; postmenopausal women | 400 mg clodronate vs. placebo | 48 h after fracture | Did not provide | BMD, function |
Harding et al. (Sweden) 2011 [14] | M and F | 25/21 | 48.9 | Patients with osteoarthritis or deformity of knee; age between 35–65 years old | 4 mg zoledronic acid vs. 9 mg/mL sodium chloride | 4 weeks postoperation | Consolidation of about two-thirds of the osteotomy gap by radiographic examination | Time to healing; BMD |
Nagahama et al. (Japan) 2011 [12] | M and F | 19/17 | 68.9 | Candidated for single-level PLIF; BMD was less than 70% of the young adult mean value | 35 mg/week alendronate vs. 1 μg/day alfacalcidol | Just postoperation | Bridging bone formation through the cage by CT scan | BMD, bone union |
Colon-Emeric et al. (USA, Norway, Belgium, Canada) 2011 [13] | M and F | 1,065/1,062 | Not reported | Patients within 90 days of hip fracture repair | 5 mg zoledronic acid vs. placebo | Within 90 days postoperation | Clinical symptoms: without persistent pain, bear weight Radiographic examination | Fracture healing |
Kim et al. (Korea) 2012 [3] | M and F | 90/0 | 76.1 | Patients with intertrochanteric fracture; BMD < −2.5 | 35 mg/week risedronate + 1,200 mg/day calcium + 800 IU/day cholecalciferol | 2 weeks vs. 1 month vs. 3 months after operation | At least two cortices bridging at the fracture site | Fracture healing, function |
Gong et al. (Korea) 2012 [15] | F | 60/0 | 66.5 | Distal radial fractures treated with plate fixation; BMD < −2.5 | 70 mg/week alendronate | 2 weeks vs. 3 months after operation | Bridging by trabeculae or osseous bone in at least one cortex as seen on anteroposterior radiographs and one as seen on lateral radiographs | Fracture healing, function; complication |
Li et al. (China) 2012 [16] | M and F | 41/41 | 63.73 | Patients undergoing TLIF | 5 mg zoledronic acid + calcium 1000 mg/day + vitamin D 400 IU/day vs. placebo + calcium 1000 mg/day + vitamin D 400 IU/day | 3 days postoperation | Bridging bony trabeculation through the cage by CT scan | Interbody fusion rate; function; biochemical assessment |