Groups
|
Femur
|
Tibia
|
---|
Surface
|
Hypocellularity
|
Clones
|
Safranin O
|
Totala
|
Surface
|
Hypocellularity
|
Clones
|
Safranin O
|
Totala
|
---|
Controls
| | | | | | | | | | |
Sham
|
0.25 ± 0.46
|
0.25 ± 0.46
|
0.00 ± 0.00
|
0.38 ± 0.52
|
0.88 ± 0.64
|
0.38 ± 0.52
|
0.38 ± 0.52
|
0.13 ± 0.35
|
0.38 ± 0.52
|
1.25 ± 1.39
|
OA
|
2.75 ± 0.46b
|
2.50 ± 0.53a
|
2.25 ± 0.89b
|
2.38 ± 0.52b
|
9.88 ± 1.13b
|
2.63 ± 0.52b
|
2.38 ± 0.52b
|
2.63 ± 0.52b
|
2.13 ± 0.83b
|
9.75 ± 1.04b
|
Diclofenac
|
2.00 ± 0.53cd
|
1.63 ± 0.52bd
|
2.25 ± 0.71b
|
1.38 ± 0.52bd
|
7.25 ± 1.39bd
|
1.88 ± 0.64be
|
1.63 ± 0.74be
|
1.75 ± 0.46bd
|
1.38 ± 0.74ce
|
6.63 ± 1.19bd
|
Calcium gluconate treated
| | | | | | | | | |
100 mg/kg
|
1.38 ± 0.74bd
|
1.25 ± 0.89bd
|
1.50 ± 0.76b
|
0.63 ± 0.52d
|
4.75 ± 1.98bd
|
1.25 ± 0.71bd
|
1.00 ± 0.76d
|
1.00 ± 0.76bd
|
1.25 ± 0.71ce
|
4.50 ± 2.20bd
|
50 mg/kg
|
2.00 ± 0.76be
|
1.50 ± 0.76bd
|
1.75 ± 0.46b
|
2.13 ± 0.35b
|
7.38 ± 1.77bd
|
2.00 ± 0.76be
|
1.63 ± 0.52be
|
1.50 ± 0.53bd
|
1.38 ± 0.74ce
|
6.50 ± 2.20bd
|
25 mg/kg
|
2.38 ± 0.74b
|
2.38 ± 0.52b
|
2.50 ± 0.53b
|
2.50 ± 0.76b
|
9.75 ± 1.16b
|
2.75 ± 0.46b
|
2.38 ± 0.74b
|
2.13 ± 0.64b
|
1.88 ± 0.83
|
9.13 ± 2.30b
|
- After 84 days of continuous oral treatment of calcium gluconate or subcutaneous treatment of diclofenac sodium in OA rats. Values are expressed as mean ± SD of eight rats, scores (Table 1). OA, osteoarthritis. aTotal means Mankin score (max = 12); bp < 0.01 and cp < 0.05 compared with those of sham control; dp < 0.01 and ep < 0.05 compared with those of OA control.