Body weight changes and knee thickness of OA rats. (A) Body weight changes in OA rats following treatment with calcium gluconate. (B) Knee thickness in OA-induced joints was significantly (p < 0.01 or p < 0.05; arrow) decreased in calcium gluconate-treated rats compared with that in OA controls. Values represent the means ± standard deviation (SD) of eight rats. OA, osteoarthritis; AO, operation day; BT, 1 day before start of treatment; AT, start day of administration; AS, at sacrifice. All animals were fasted overnight prior to the start of administration and sacrifice.