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Table 3 Statistical analysis of gene expression profiles of 3D cartilage grafts in vitro

From: An ovine in vitro model for chondrocyte-based scaffold-assisted cartilage grafts

gene point in time rel. expression mean %GAPDH SD p-value vs. 1 week 3D p-value vs. 2 weeks 3D p-value vs. 3 weeks 3D
type 2α1 collagen P3 0.34 0.15 0.0066 0.0039 0.0547
1 week 3D (P3) 1.50 1.00 --- 0.0248 0.4258
2 weeks 3D (P3) 3.42 2.23 0.0248 --- 0.9102
3 weeks 3D (P3) 5.09 6.78 0.4258 0.9102 ---
P5 0.07 0.06 0.0104 0.0028 0.0039
1 week 3D (P5) 0.19 0.08 --- 0.0288 0.0039
2 weeks 3D (P5) 0.40 0.21 0.0288 --- 0.0160
3 weeks 3D (P5) 1.48 0.84 0.0039 0.0160 ---
Aggrecan P3 2.60 1.91 0.0153 0.0031 0.0547
1 week 3D (P3) 6.69 5.47 --- 0.0094 0.4547
2 weeks 3D (P3) 16.91 12.05 0.0094 --- 0.0039
3 weeks 3D (P3) 8.04 8.41 0.4547 0.0039 ---
P5 1.05 0.32 0.0309 0.0039 0.0002
1 week 3D (P5) 2.16 1.11 --- 0.0039 0.0039
2 weeks 3D (P5) 6.27 4.56 0.0039 --- 0.9449
3 weeks 3D (P5) 6.41 2.29 0.0039 0.9449 ---
MMP1 P3 0.34 0.12 0.0039 0.0305 0.0008
1 week 3D (P3) 3.96 4.48 --- 0.0078 0.0039
2 weeks 3D (P3) 1.20 1.07 0.0078 --- 0.0009
3 weeks 3D (P3) 0.13 0.16 0.0039 0.0009 ---
P5 0.23 0.14 0.0039 0.0029 0.0002
1 week 3D (P5) 3.52 4.00 --- 0.0039 0.0039
2 weeks 3D (P5) 0.57 0.30 0.0039 --- 0.9449
3 weeks 3D (P5) 0.07 0.10 0.0039 0.9449 ---
MMP2 P3 20.81 26.32 0.0030 0.0032 0.0218
1 week 3D (P3) 52.38 38.09 --- 0.4360 0.0058
2 weeks 3D (P3) 57.71 37.25 0.4360 --- 0.0159
3 weeks 3D (P3) 33.18 34.32 0.0058 0.0159 ---
P5 14.42 10.10 0.0118 0.0232 0.0001
1 week 3D (P5) 28.02 20.84 --- 0.4063 0.2593
2 weeks 3D (P5) 33.47 28.82 0.4063 --- 0.8868
3 weeks 3D (P5) 34.49 12.90 0.2593 0.8868 ---
MMP13 P3 1.65 1.42 0.0078 0.0276 0.0039
1 week 3D (P3) 23.86 18.88 --- 0.0151 0.0039
2 weeks 3D (P3) 8.68 6.96 0.0151 --- 0.2867
3 weeks 3D (P3) 4.78 4.75 0.0039 0.2867 ---
P5 0.74 0.38 0.0008 0.0052 0.0557
1 week 3D (P5) 19.00 10.39 --- 0.0011 0.0008
2 weeks 3D (P5) 1.87 1.08 0.0011 --- 0.0020
3 weeks 3D (P5) 0.60 0.51 0.0008 0.0020 ---
TIMP1 P3 497.9 211.8 0.3558 0.7333 0.0171
1 week 3D (P3) 561.2 189.7 --- 0.5256 0.0015
2 weeks 3D (P3) 512.1 258.1 0.5256 --- 0.0133
3 weeks 3D (P3) 303.6 240.8 0.0015 0.0133 ---
P5 615.6 334.5 0.2188 0.5559 0.0391
1 week 3D (P5) 463.3 49.7 --- 0.0364 0.3946
2 weeks 3D (P5) 676.0 229.4 0.0364 --- 0.0023
3 weeks 3D (P5) 422.5 121.7 0.3946 0.0023 ---
TIMP2 P3 83.0 46.5 0.2066 0.3109 0.2574
1 week 3D (P3) 119.4 43.7 --- 0.6909 0.0848
2 weeks 3D (P3) 109.8 48.5 0.6909 --- 0.0907
3 weeks 3D (P3) 63.4 53.1 0.0848 0.0907 ---
P5 97.7 35.1 0.5837 0.4985 0.9227
1 week 3D (P5) 110.2 55.4 --- 0.2950 0.4336
2 weeks 3D (P5) 86.1 19.3 0.2950 --- 0.3490
  3 weeks 3D (P5) 96.2 26.2 0.4336 0.3490 ---
TIMP3 P3 83.2 30.5 0.0003 0.0008 0.0097
1 week 3D (P3) 204.0 67.5 --- 0.0061 0.0078
2 weeks 3D (P3) 156.5 46.4 0.0061 --- 0.0730
3 weeks 3D (P3) 99.8 98.9 0.0078 0.0730 ---
P5 120.4 35.4 0.0488 0.0195 0.0097
1 week 3D (P5) 187.2 85.9 --- 0.7876 0.1902
2 weeks 3D (P5) 197.7 69.9 0.7876 --- 0.0888
3 weeks 3D (P5) 282.2 167.3 0.1902 0.0888 ---