Skip to main content

Table 4 Histomorphometric data at 24 weeks post-OVX in metaphyseal regions of the tibiae

From: Alendronate (ALN) combined with Osteoprotegerin (OPG) significantly improves mechanical properties of long bone than the single use of ALN or OPG in the ovariectomized rats

Treatment Group Tb.Ar (%) Trabecular thickness (μm) Min. surface (%) Mineral apposition rate (μm/day) BFR/BS (μm/day) Osteoclast number (no/mm)
Sham 49.0 ± 9.23 a 74.2 ± 11.34 a 21.4 ± 3.3 a 0.7 ± 0.13 a 16.2 ± 1.45 a 0.36 ± 0.03 a
OVX 11.6 ± 5.81 45.2 ± 10.61 33.2 ± 4.6 1.2 ± 0.1 35.7 ± 2.30 1.12 ± 10.61
OVX+ALN 59.7 ± 8.29 a 90.0 ± 17.65 a,b 28.1 ± 1.44 a 0.9 ± 0.0 a 24.6 ± 1.11 a 0.24 ± 0.04 a,b
OVX+OPG-Fc 44.5 ± 6.72 a 71.1 ± 27.19 a 27.8 ± 2.17 a 0.7 ± 0.0 a 23.1 ± 2.11 a 0.15 ± 0.04 a,b
OVX+ALN+OPG-Fc 62.3 ± 9.34 a, b 93.7 ± 13.97 a,b 22.1 ± 3.71 a 0.6 ± 0.09 a 17.7 ± 1.94 a 0.05 ± 0.00 a,b
  1. Data were presented as mean ± SEM.
  2. (a): Group had significantly higher or lower value than that of the OVX group, p < 0.05.
  3. (b): Group had significantly higher or lower value than that of the sham group, p < 0.05.