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Table 3 Mechanical properties of L3 vertebra and femoral shaft at 24 weeks post-OVX

From: Alendronate (ALN) combined with Osteoprotegerin (OPG) significantly improves mechanical properties of long bone than the single use of ALN or OPG in the ovariectomized rats

Groups (L3 vertebra) Ultimate load (N) Ultimate stress (N/mm2)
Sham 314.89 ± 22.87 46.30 ± 2.65
OVX 217.46 ± 33.04a 27.88 ± 4.23 a
OVX+ALN 294.75 ± 25.58 37.79 ± 2.78
OVX+OPG-Fc 275.30 ± 28.77 35.29 ± 1.35
OVX+ALN+OPG-Fc 312.91 ± 41.76 b 40.12 ± 2.53 b
Groups (Femoral shaft) Ultimate load (N) Ultimate stress (N/mm2)
Sham 125.79 ± 11.19 187.14 ± 33.01
OVX 104.88 ± 6.21 a 146.57 ± 12.75 a
OVX+ALN 130.83 ± 9.11 179.91 ± 13.01
OVX+OPG-Fc 124.72 ± 6.78 174.65 ± 12.15
OVX+ALN+OPG-Fc 127.55 ± 7.49 b 176.89 ± 17.44 b
  1. Data were presented as mean ± SEM.
  2. (a): Group had significantly lower value than that of the sham group at the given time, p < 0.01.
  3. (b): Group had significantly higher value than that of the OVX group at the given time, p < 0.01.