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Table 3 Mechanical properties of L3 vertebra and femoral shaft at 24 weeks post-OVX

From: Alendronate (ALN) combined with Osteoprotegerin (OPG) significantly improves mechanical properties of long bone than the single use of ALN or OPG in the ovariectomized rats

Groups (L3 vertebra)

Ultimate load (N)

Ultimate stress (N/mm2)

Sham

314.89 ± 22.87

46.30 ± 2.65

OVX

217.46 ± 33.04a

27.88 ± 4.23 a

OVX+ALN

294.75 ± 25.58

37.79 ± 2.78

OVX+OPG-Fc

275.30 ± 28.77

35.29 ± 1.35

OVX+ALN+OPG-Fc

312.91 ± 41.76 b

40.12 ± 2.53 b

Groups (Femoral shaft)

Ultimate load (N)

Ultimate stress (N/mm2)

Sham

125.79 ± 11.19

187.14 ± 33.01

OVX

104.88 ± 6.21 a

146.57 ± 12.75 a

OVX+ALN

130.83 ± 9.11

179.91 ± 13.01

OVX+OPG-Fc

124.72 ± 6.78

174.65 ± 12.15

OVX+ALN+OPG-Fc

127.55 ± 7.49 b

176.89 ± 17.44 b

  1. Data were presented as mean ± SEM.
  2. (a): Group had significantly lower value than that of the sham group at the given time, p < 0.01.
  3. (b): Group had significantly higher value than that of the OVX group at the given time, p < 0.01.